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(STZ, 65mg\/kg)\u7834\u58deβ\u7d30\u80de\uff0c\u4f7f\u80f0\u5cf6\u7d20\u7121\u6cd5\u5206\u6ccc\uff0c\u9020\u6210\u8840\u7cd6\u5347\u9ad8\u800c\u8a98\u5c0e\u6210\u7cd6\u5c3f\u75c5\u9f20\u3002\u4e26\u9032\u4e00\u6b65\u63a2\u8a0e\u6d77\u6d0b\u6df1\u5c64\u6c34\u9632\u6cbb\u7cd6\u5c3f\u75c5\u4f75\u767c\u5fc3\u808c\u80a5\u539a\u548c\u51cb\u4ea1\u7684\u5206\u5b50\u8a0a\u606f\u6a5f\u8f49\u3002\u6cbb\u7642\u7684\u65b9\u5f0f\u5247\u5206\u5225\u7ba1\u9935STZ\u7cd6\u5c3f\u75c5\u9f20 1X(37 mg\/kg\/day\uff09\u30012X(74 mg\/kg\/day\uff09\u30013X(111 mg\/kg\/day)\u4e0d\u540c\u500d\u6578\u7684\u6d77\u6d0b\u6df1\u5c64\u6c344\u9031\u3002\u5be6\u9a57\u986f\u793a\u6d77\u6d0b\u6df1\u5c64\u6c34\u4e0d\u4f46\u986f\u8457\u964d\u4f4e\u7cd6\u5c3f\u75c5\u9f20\u4e4b\u8840\u7cd6\u66f4\u660e\u986f\u6e1b\u4f4e\u6b7b\u4ea1\u63d0\u5347\u7cd6\u5c3f\u75c5\u9f20\u4e4b\u5b58\u6d3b\u7387\uff0c\u4e26\u4ee5\u5fc3\u808c\u8d85\u97f3\u6ce2(ECHO)\u3001\u7d44\u7e54\u67d3\u8272\u5207\u7247\u3001TUNEL 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assay\u4e2d\u8b49\u5be6\u7cd6\u5c3f\u75c5\u6703\u9020\u6210\u7d30\u80de\u51cb\u4ea1\uff0c\u4fc3\u4f7f\u67d3\u8272\u9ad4DNA\u96d9\u80a1\u5927\u91cf\u65b7\u88c2\uff0c\u4f46\u7d66\u4e882X\u6d77\u6d0b\u6df1\u5c64\u6c34\u7684\u52d5\u7269\u5fc3\u808c\u7d44\u7e54\u4e2d\u7d30\u80deDNA\u65b7\u88c2\u73fe\u8c61\u660e\u986f\u88ab\u6291\u5236\uff0c\u964d\u4f4e\u51cb\u4ea1\u7684\u4fdd\u8b77\u6548\u679c\u6700\u70ba\u660e\u986f\u3002\u5728\u4ee5\u897f\u65b9\u58a8\u9ede\u6cd5(western blotting)\u6e2c\u91cf\u751f\u5316\u8a0a\u606f\u86cb\u767d\u4e2d\uff0c\u767c\u73fe\u6d77\u6d0b\u6df1\u5c64\u6c34\u9935\u98df\u4e0d\u4f46\u6291\u5236TNF-α-NFkB\u767c\u708e\u8a0a\u606f\u9014\u5f91\u66f4\u6709\u6548\u64f7\u6297IL6-MEK5-ERK5\u53caIGFIIR-Gaq-Calcineurin-NFAT3\u5fc3\u808c\u80a5\u5927\u8a0a\u606f\u9014\u5f91\u3002\u540c\u6642\u7cd6\u5c3f\u75c5\u7684\u7d44\u5225\u4e2d\uff0c\u5fc3\u808c\u51cb\u4ea1\u5305\u62ecdeath-dependent\u548cmitochondria-dependent 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