\u6c23\u7403\u64f4\u5f35\u8853\uff08balloon angioplasty\uff1bBA\uff09\u662f\u4e00\u9805\u904b\u7528\u65bc\u6cbb\u7642\u6025\u6027\u52d5\u8108\u963b\u585e\uff08\u4f8b\u5982\u5fc3\u808c\u6897\u585e\uff09\u7684\u5fc3\u81df\u5167\u79d1\u624b\u8853\uff0c\u4f46\u537b\u6709\u9ad8\u6bd4\u4f8b\u7684\u60a3\u8005\u8853\u5f8c\u7522\u751f\u8840\u7ba1\u518d\u963b\u585e\uff08restenosis\uff09\u7684\u4f75\u767c\u75c71-4\u3002\u8840\u7ba1\u518d\u963b\u585e\u662f\u8840\u7ba1\u58c1\u53d7\u640d\u5f8c\u7684\u7570\u5e38\u4fee\u5fa9\u73fe\u8c61\uff0c\u5176\u6210\u56e0\u53ef\u6b78\u7d0d\u70ba\u8840\u7ba1\u5167\u819c\u589e\u751f\uff08intimal hyperplasia\uff09\u548c\u7d50\u69cb\u6027\u91cd\u6574\uff08remodeling\uff095-8\u3002\u5176\u4e2d\uff0c\u4ee5\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u6210\u56e0\u70ba\u591a\u6578\u5b78\u8005\u6240\u63a1\u7d0d\u3002\u800c\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u7684\u904e\u5ea6\u589e\u751f\u8207\u9077\u79fb\u5728\u5176\u4e2d\u626e\u6f14\u6700\u91cd\u8981\u7684\u75c5\u7406\u89d2\u82729-10\uff0c\u56e0\u6b64\u6210\u70ba\u958b\u767c\u9810\u9632\u85e5\u7269\u6216\u4fdd\u5065\u98df\u54c1\u7684\u6f5b\u5728\u8a55\u4f30\u6a19\u7684\u3002<\/p>\n
\u6d77\u6d0b\u8cc7\u6e90\u8c50\u5bcc\uff0c\u800c\u6df1\u5c64\u6d77\u6c34\u76f8\u95dc\u7684\u7522\u54c1\u958b\u767c\u61c9\u7528\u66f4\u662f\u76ee\u524d\u71b1\u9580\u7684\u7814\u767c\u65b9\u5411\u3002\u9664\u5df2\u5ee3\u6cdb\u7684\u88ab\u61c9\u7528\u65bc\u8fb2\u6f01\u696d\u990a\u6b96\u3001\u5316\u599d\u54c1\u3001\u98f2\u6599\u696d\u5916\uff0c\u5728\u4fdd\u5065\u7522\u54c1\u548c\u85e5\u7269\u7684\u958b\u767c\u4ea6\u6df1\u5177\u5e02\u5834\u6f5b\u529b\u548c\u7d93\u6fdf\u50f9\u503c\u3002\u6d77\u6c34\u5bcc\u542b\u591a\u7a2e\u6709\u6a5f\u6216\u7926\u7269\u8cea\u6210\u5206\uff0c\u5176\u4e2d\u53c8\u4ee5\u9382\u96e2\u5b50\u7684\u4fdd\u5065\u529f\u6548\u6700\u88ab\u773e\u6240\u719f\u77e5\u548c\u7814\u7a76\u95dc\u6ce8\u3002\u773e\u591a\u7814\u7a76\u4ea6\u986f\u793a\uff0c\u9382\u96e2\u5b50\u5177\u6709\u6e1b\u5c11\u7f79\u60a3\u591a\u7a2e\u75be\u75c5\uff08\u4f8b\u5982\u9ad8\u8840\u58d3\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u75c7\u3001\u5fc3\u808c\u6897\u585e\u3001\u7cd6\u5c3f\u75c5\u548c\u764c\u75c7\uff09\u7684\u6f5b\u529b\u3002\u800c\u7814\u7a76\u4e5f\u8b49\u5be6\u9382\u96e2\u5b50\u5177\u6709\u6291\u5236\u4eba\u985e\u51a0\u72c0\u52d5\u8108\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u529f\u6548\uff0c\u5176\u4f5c\u7528\u6a5f\u5236\u727d\u6d89\u5305\u62ec\u7d30\u80de\u5167\u751f\u9577\u56e0\u5b50\u53ca\u5176\u63a5\u53d7\u5668\u548c\u4e0b\u6e38\u5206\u5b50\u50b3\u905e\u9014\u5f91\uff0c\u4ee5\u53ca\u7d30\u80de\u9031\u671f\u548c\u7d30\u80de\u51cb\u4ea1\u7b49\u773e\u591a\u5206\u5b50\u5728\u5167\u7684\u57fa\u56e0\u8abf\u63a711\u3002\u9019\u7d50\u679c\u66f4\u652f\u6301\u4e86\u9382\u96e2\u5b50\u5728\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u61c9\u7528\u6f5b\u529b\u3002\u540c\u6a23\u5730\uff0c\u98f2\u7528\u6df1\u5c64\u6d77\u6c34\u4e5f\u88ab\u6307\u51fa\u63d0\u4f9b\u591a\u7a2e\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u529f\u6548\u8207\u4f5c\u7528\uff0c\u5305\u62ec\u9810\u9632\u9ad8\u8840\u8102\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u548c\u9ad8\u8840\u58d3\uff0c\u4ee5\u53ca\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7b49\u529f\u654812-14\u3002<\/p>\n
\u8fd1\u671f\uff0c\u6211\u5011\u91dd\u5c0d\u4e0d\u540c\u7926\u7269\u8cea\u7d44\u6210\u4e4b\u6df1\u5c64\u6d77\u6c34\u6fc3\u7e2e\u6db2\uff08DSC\uff09\u9032\u884c\u4e86\u4e00\u7cfb\u5217\u6d3b\u6027\u8a55\u4f30\uff0c\u4ee5\u77ad\u89e3\u9664\u4e86\u9382\u96e2\u5b50\u5916\uff0c\u6df1\u5c64\u6d77\u6c34\u4e2d\u662f\u5426\u5b58\u5728\u5176\u4ed6\u5177\u5099\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u6d3b\u6027\u6210\u5206\uff0c\u4ee5\u53ca\u4e0d\u540c\u7522\u54c1\u88fd\u7a0b\u5c0d\u6d3b\u6027\u7684\u5f71\u97ff\u3002\u5728\u7d30\u80de\u589e\u751f\u5be6\u9a57\uff08MTT assay\uff09\u4e2d\uff0c\u767c\u73fe\u6df1\u5c64\u6d77\u6c34\u7684\u9152\u7cbe\u8403\u53d6\u6db2\uff08DSC-DOM\uff09\u5c0d\u6291\u5236\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u6548\u679c\u6700\u986f\u8457\uff0c\u6bd4\u6b63\u5c0d\u7167\u7d44\uff08\u6c27\u5316\u9382\uff1bMgCl2\uff09\u6548\u679c\u66f4\u4f73\u3002\u800c\u5305\u62ec\u9ad8\u9382\u7121\u9223\u6fc3\u7e2e\u6db2\uff08DSC-DeCa\uff09\u3001\u9ad8\u9223\u9ad8\u9382\u6fc3\u7e2e\u6db2\uff08DSC-HiCa\uff09\u548c\u6e1b\u58d3\u6fc3\u7e2e\u6db2\uff08DSC-RP\uff09\u5728\u5167\u7684\u5176\u4ed6\u7d44\u5225\uff0c\u5176\u6291\u5236\u6548\u679c\u8207\u6b63\u5c0d\u7167\u7d44\u76f8\u7576\uff08\u5716\uff11\uff09\u3002\u800c\u7d93\u9032\u4e00\u6b65\u5206\u6790\u4e0d\u540cDSC\u5c0d\u7d30\u80de\u9031\u671f\u7684\u8abf\u63a7\u5f71\u97ff\u6307\u51fa\uff0cMgCl2\u4e3b\u8981\u662f\u9020\u6210\u7d30\u80de\u751f\u9577\u6291\u5236\uff08\u505c\u6eef\u65bcG0\/G1\u671f\uff09\uff0c\u4e26\u7a0d\u5177\u7d30\u80de\u51cb\u4ea1\uff08Sub-G1\u6bd4\u4f8b\u589e\u52a0\uff09\u4f5c\u7528\u3002\u800cDSC-DeCa\u5247\u4e3b\u8981\u5c0e\u81f4\u7d30\u80de\u51cb\u4ea1\uff0c\u4f46\u6709\u90e8\u5206\u4fc3\u7d30\u80de\u505c\u6eef\u7684\u6548\u679c\u3002DSC-HiCa\u53ea\u6709\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\u3002\u800cDSC-RP\u548cDSC-DOM\u5247\u540c\u6642\u5177\u5099\u6291\u5236\u7d30\u80de\u751f\u9577\u548c\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\uff08\u57162\uff09\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7d30\u80de\u9077\u79fb\u5206\u6790\u6cd5\uff08wound healing assay\uff09\u7684\u5be6\u9a57\u4e2d\uff0c\u5247\u986f\u793aMgCl2\u548c\u6240\u6709DSC\u7522\u54c1\u7686\u5177\u6709\u986f\u8457\u6291\u5236\u7d30\u80de\u9077\u79fb\u7684\u985e\u4f3c\u529f\u6548\uff08\u57163\uff09\u3002\u800c\u5728\u8207\u7d30\u80de\u589e\u751f\u6216\u9077\u79fb\u76f8\u95dc\u4e4b\u5206\u5b50\u9014\u5f91\uff08PI3K-AKT\u3001ERK1\/2-MAPK\u548cAMPK\uff09\u7684\u8abf\u63a7\u5f71\u97ff\u65b9\u9762\uff08\u57164\uff09\u3002MgCl2\u548c\u4e0d\u540cDSC\uff08\u9664DSC-DOM\u7d44\u5916\uff09\u7686\u53ef\u986f\u8457\u6291\u5236\u8840\u6e05\u6240\u6d3b\u5316\u7684ERK1\/2-MAPK\u5206\u5b50\u9014\u5f91\uff0c\u4ee5\u53ca\u4fc3\u4f7fAMPK\u6d3b\u5316\u3002\u800c\u6d3b\u5316AMPK\u7684\u6548\u679c\uff0c\u53c8\u4ee5DSC-HiCa\u548cDSC-RP\u7684\u4f5c\u7528\u7a81\u51fa\u3002\u4f46DSC-DOM\u5728\u6e2c\u8a66\u6c23\u7403\u64f4\u5f35\u8853\uff08balloon angioplasty\uff1bBA\uff09\u662f\u4e00\u9805\u904b\u7528\u65bc\u6cbb\u7642\u6025\u6027\u52d5\u8108\u963b\u585e\uff08\u4f8b\u5982\u5fc3\u808c\u6897\u585e\uff09\u7684\u5fc3\u81df\u5167\u79d1\u624b\u8853\uff0c\u4f46\u537b\u6709\u9ad8\u6bd4\u4f8b\u7684\u60a3\u8005\u8853\u5f8c\u7522\u751f\u8840\u7ba1\u518d\u963b\u585e\uff08restenosis\uff09\u7684\u4f75\u767c\u75c7<\/p>\n
1-4<\/p>\n
\u3002\u8840\u7ba1\u518d\u963b\u585e\u662f\u8840\u7ba1\u58c1\u53d7\u640d\u5f8c\u7684\u7570\u5e38\u4fee\u5fa9\u73fe\u8c61\uff0c\u5176\u6210\u56e0\u53ef\u6b78\u7d0d\u70ba\u8840\u7ba1\u5167\u819c\u589e\u751f\uff08intimal hyperplasia\uff09\u548c\u7d50\u69cb\u6027\u91cd\u6574\uff08remodeling\uff09<\/p>\n
5-8<\/p>\n
\u3002\u5176\u4e2d\uff0c\u4ee5\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u6210\u56e0\u70ba\u591a\u6578\u5b78\u8005\u6240\u63a1\u7d0d\u3002\u800c\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u7684\u904e\u5ea6\u589e\u751f\u8207\u9077\u79fb\u5728\u5176\u4e2d\u626e\u6f14\u6700\u91cd\u8981\u7684\u75c5\u7406\u89d2\u8272<\/p>\n
9-10<\/p>\n
\uff0c\u56e0\u6b64\u6210\u70ba\u958b\u767c\u9810\u9632\u85e5\u7269\u6216\u4fdd\u5065\u98df\u54c1\u7684\u6f5b\u5728\u8a55\u4f30\u6a19\u7684\u3002<\/p>\n
\u6d77\u6d0b\u8cc7\u6e90\u8c50\u5bcc\uff0c\u800c\u6df1\u5c64\u6d77\u6c34\u76f8\u95dc\u7684\u7522\u54c1\u958b\u767c\u61c9\u7528\u66f4\u662f\u76ee\u524d\u71b1\u9580\u7684\u7814\u767c\u65b9\u5411\u3002\u9664\u5df2\u5ee3\u6cdb\u7684\u88ab\u61c9\u7528\u65bc\u8fb2\u6f01\u696d\u990a\u6b96\u3001\u5316\u599d\u54c1\u3001\u98f2\u6599\u696d\u5916\uff0c\u5728\u4fdd\u5065\u7522\u54c1\u548c\u85e5\u7269\u7684\u958b\u767c\u4ea6\u6df1\u5177\u5e02\u5834\u6f5b\u529b\u548c\u7d93\u6fdf\u50f9\u503c\u3002\u6d77\u6c34\u5bcc\u542b\u591a\u7a2e\u6709\u6a5f\u6216\u7926\u7269\u8cea\u6210\u5206\uff0c\u5176\u4e2d\u53c8\u4ee5\u9382\u96e2\u5b50\u7684\u4fdd\u5065\u529f\u6548\u6700\u88ab\u773e\u6240\u719f\u77e5\u548c\u7814\u7a76\u95dc\u6ce8\u3002\u773e\u591a\u7814\u7a76\u4ea6\u986f\u793a\uff0c\u9382\u96e2\u5b50\u5177\u6709\u6e1b\u5c11\u7f79\u60a3\u591a\u7a2e\u75be\u75c5\uff08\u4f8b\u5982\u9ad8\u8840\u58d3\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u75c7\u3001\u5fc3\u808c\u6897\u585e\u3001\u7cd6\u5c3f\u75c5\u548c\u764c\u75c7\uff09\u7684\u6f5b\u529b\u3002\u800c\u7814\u7a76\u4e5f\u8b49\u5be6\u9382\u96e2\u5b50\u5177\u6709\u6291\u5236\u4eba\u985e\u51a0\u72c0\u52d5\u8108\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u529f\u6548\uff0c\u5176\u4f5c\u7528\u6a5f\u5236\u727d\u6d89\u5305\u62ec\u7d30\u80de\u5167\u751f\u9577\u56e0\u5b50\u53ca\u5176\u63a5\u53d7\u5668\u548c\u4e0b\u6e38\u5206\u5b50\u50b3\u905e\u9014\u5f91\uff0c\u4ee5\u53ca\u7d30\u80de\u9031\u671f\u548c\u7d30\u80de\u51cb\u4ea1\u7b49\u773e\u591a\u5206\u5b50\u5728\u5167\u7684\u57fa\u56e0\u8abf\u63a7<\/p>\n
11<\/p>\n
\u3002\u9019\u7d50\u679c\u66f4\u652f\u6301\u4e86\u9382\u96e2\u5b50\u5728\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u61c9\u7528\u6f5b\u529b\u3002\u540c\u6a23\u5730\uff0c\u98f2\u7528\u6df1\u5c64\u6d77\u6c34\u4e5f\u88ab\u6307\u51fa\u63d0\u4f9b\u591a\u7a2e\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u529f\u6548\u8207\u4f5c\u7528\uff0c\u5305\u62ec\u9810\u9632\u9ad8\u8840\u8102\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u548c\u9ad8\u8840\u58d3\uff0c\u4ee5\u53ca\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7b49\u529f\u6548<\/p>\n
12-14<\/p>\n
\u3002<\/p>\n
\u8fd1\u671f\uff0c\u6211\u5011\u91dd\u5c0d\u4e0d\u540c\u7926\u7269\u8cea\u7d44\u6210\u4e4b\u6df1\u5c64\u6d77\u6c34\u6fc3\u7e2e\u6db2\uff08DSC\uff09\u9032\u884c\u4e86\u4e00\u7cfb\u5217\u6d3b\u6027\u8a55\u4f30\uff0c\u4ee5\u77ad\u89e3\u9664\u4e86\u9382\u96e2\u5b50\u5916\uff0c\u6df1\u5c64\u6d77\u6c34\u4e2d\u662f\u5426\u5b58\u5728\u5176\u4ed6\u5177\u5099\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u6d3b\u6027\u6210\u5206\uff0c\u4ee5\u53ca\u4e0d\u540c\u7522\u54c1\u88fd\u7a0b\u5c0d\u6d3b\u6027\u7684\u5f71\u97ff\u3002\u5728\u7d30\u80de\u589e\u751f\u5be6\u9a57\uff08MTT assay\uff09\u4e2d\uff0c\u767c\u73fe\u6df1\u5c64\u6d77\u6c34\u7684\u9152\u7cbe\u8403\u53d6\u6db2\uff08DSC-DOM\uff09\u5c0d\u6291\u5236\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u6548\u679c\u6700\u986f\u8457\uff0c\u6bd4\u6b63\u5c0d\u7167\u7d44\uff08\u6c27\u5316\u9382\uff1bMgCl2<\/sub>\uff09\u6548\u679c\u66f4\u4f73\u3002\u800c\u5305\u62ec\u9ad8\u9382\u7121\u9223\u6fc3\u7e2e\u6db2\uff08DSC-DeCa\uff09\u3001\u9ad8\u9223\u9ad8\u9382\u6fc3\u7e2e\u6db2\uff08DSC-HiCa\uff09\u548c\u6e1b\u58d3\u6fc3\u7e2e\u6db2\uff08DSC-RP\uff09\u5728\u5167\u7684\u5176\u4ed6\u7d44\u5225\uff0c\u5176\u6291\u5236\u6548\u679c\u8207\u6b63\u5c0d\u7167\u7d44\u76f8\u7576\uff08<\/p>\n \u5716\uff11<\/p>\n \uff09\u3002\u800c\u7d93\u9032\u4e00\u6b65\u5206\u6790\u4e0d\u540cDSC\u5c0d\u7d30\u80de\u9031\u671f\u7684\u8abf\u63a7\u5f71\u97ff\u6307\u51fa\uff0cMgCl2<\/sub>\u4e3b\u8981\u662f\u9020\u6210\u7d30\u80de\u751f\u9577\u6291\u5236\uff08\u505c\u6eef\u65bcG0\/G1\u671f\uff09\uff0c\u4e26\u7a0d\u5177\u7d30\u80de\u51cb\u4ea1\uff08Sub-G1\u6bd4\u4f8b\u589e\u52a0\uff09\u4f5c\u7528\u3002\u800cDSC-DeCa\u5247\u4e3b\u8981\u5c0e\u81f4\u7d30\u80de\u51cb\u4ea1\uff0c\u4f46\u6709\u90e8\u5206\u4fc3\u7d30\u80de\u505c\u6eef\u7684\u6548\u679c\u3002DSC-HiCa\u53ea\u6709\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\u3002\u800cDSC-RP\u548cDSC-DOM\u5247\u540c\u6642\u5177\u5099\u6291\u5236\u7d30\u80de\u751f\u9577\u548c\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\uff08<\/p>\n \u57162<\/p>\n \uff09\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7d30\u80de\u9077\u79fb\u5206\u6790\u6cd5\uff08wound healing assay\uff09\u7684\u5be6\u9a57\u4e2d\uff0c\u5247\u986f\u793aMgCl2<\/sub>\u548c\u6240\u6709DSC\u7522\u54c1\u7686\u5177\u6709\u986f\u8457\u6291\u5236\u7d30\u80de\u9077\u79fb\u7684\u985e\u4f3c\u529f\u6548\uff08<\/p>\n \u57163<\/p>\n \uff09\u3002\u800c\u5728\u8207\u7d30\u80de\u589e\u751f\u6216\u9077\u79fb\u76f8\u95dc\u4e4b\u5206\u5b50\u9014\u5f91\uff08PI3K-AKT\u3001ERK1\/2-MAPK\u548cAMPK\uff09\u7684\u8abf\u63a7\u5f71\u97ff\u65b9\u9762\uff08<\/p>\n \u57164<\/p>\n \uff09\u3002MgCl2<\/sub>\u548c\u4e0d\u540cDSC\uff08\u9664DSC-DOM\u7d44\u5916\uff09\u7686\u53ef\u986f\u8457\u6291\u5236\u8840\u6e05\u6240\u6d3b\u5316\u7684ERK1\/2-MAPK\u5206\u5b50\u9014\u5f91\uff0c\u4ee5\u53ca\u4fc3\u4f7fAMPK\u6d3b\u5316\u3002\u800c\u6d3b\u5316AMPK\u7684\u6548\u679c\uff0c\u53c8\u4ee5DSC-HiCa\u548cDSC-RP\u7684\u4f5c\u7528\u7a81\u51fa\u3002\u4f46DSC-DOM\u5728\u6e2c\u8a66\u7684\u6fc3\u5ea6\u4e0b\uff0c\u5c0d\u6240\u6709\u8a55\u4f30\u7684\u5206\u5b50\u7686\u7121\u660e\u986f\u7684\u8abf\u63a7\u6548\u679c\u3002\u6211\u5011\u4e5f\u5229\u7528\u5927\u9f20\u9838\u52d5\u8108\u6c23\u7403\u64f4\u5f35\u8853\u7684\u6d3b\u9ad4\u8a55\u4f30\u6a21\u5f0f\u4f86\u8a55\u4f30\u4e0d\u540cDSC\u9810\u9632\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u6548\u679c\uff08<\/p>\n \u57165<\/p>\n \uff09\u3002\u7d44\u7e54\u75c5\u7406\u5b78\u7684\u5206\u6790\u4e2d\uff0c\u8ca0\u5c0d\u7167\u7d44\uff08RO\u548cEtOH\u7d44\uff1b\u6eb6\u5a92\u7d44\uff09\u7684\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u56b4\u91cd\u6027\u6307\u6a19\uff08ratio of neointima-to-media area\uff1b\uff2e\/M ratio\uff09\u505a\u70ba\u6bd4\u8f03\u7684\u57fa\u6e96\u3002\u800c\u6295\u8207MgCl2<\/sub>\u3001DSC-DeCa\u6216DSC-HiCa\u5f8c\uff0c\u5176N\/M ratio\u6709\u8f03RO\u7d44\u6e1b\u5c11\u7684\u8da8\u52e2\u3002\u800cDSC-RP\u7d44\u5247\u4f3c\u4e4e\u6c92\u6709\u986f\u8457\u6291\u5236\u6548\u679c\u3002\u7136\u800c\uff0c\u6295\u8207DSC-DOM\u5f8c\uff0c\u5176N\/M ratio\u8f03EtOH\u7d44\u4e5f\u6709\u964d\u4f4e\u7684\u8da8\u52e2\uff0c\u4e14\u5176N\/M ratio\u4e5f\u662f\u6240\u6709DSC\u7d44\u5225\u4e2d\u6700\u5c0f\u8005\u3002<\/p>\n \u7d9c\u5408\u6211\u5011\u8fd1\u671f\u7684\u5be6\u9a57\u6210\u679c\u986f\u793a\uff0c\u96d6\u7136\u4e0d\u540cDSC\u7522\u54c1\u5c0d\u65bc\u6291\u5236\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u8207\u9077\u79fb\u7684\u80fd\u529b\u76f8\u8fd1\u3002\u4f46\u82e5\u9032\u4e00\u6b65\u63a2\u8a0e\u4e0d\u540cDSC\u7522\u54c1\u5c0d\u7d30\u80de\u751f\u9577\u6216\u7d30\u80de\u9031\u671f\u76f8\u95dc\u5206\u5b50\u7684\u8abf\u63a7\u5dee\u7570\uff0c\u5247\u6703\u767c\u73fe\u5176\u8abf\u63a7\u6a5f\u5236\u6216\u4f5c\u7528\u5f37\u5ea6\u4e26\u4e0d\u76f8\u540c\u3002\u9019\u4e9b\u5dee\u7570\u986f\u793a\u88fd\u7a0b\u53c3\u6578\u7684\u6539\u8b8a\uff08\u4f8b\u5982\u6eab\u5ea6\u6216\u812b\u9e7d\u65b9\u6cd5\uff09\u78ba\u5be6\u6703\u5f71\u97ffDSC\u7684\u5fc3\u8840\u7ba1\u4fdd\u8b77\u4f5c\u7528\uff0c\u800c\u5176\u4e2d\u53ef\u80fd\u539f\u56e0\u5305\u62ec\u7121\u6a5f\u96e2\u5b50\u6216\u6709\u6a5f\u7269\u6d3b\u6027\u6210\u5206\u7684\u6bd4\u4f8b\u8b8a\u5316\u6216\u71b1\u5931\u6d3b\u3002\u7d9c\u5408\u76f8\u95dc\u5be6\u9a57\u6578\u64da\uff0c\u4ee5\u6295\u8207DSC-DOM\u7684\u6291\u5236\u6548\u679c\u6700\u70ba\u986f\u8457\uff0c\u4e5f\u6df1\u5177\u505a\u70ba\u8840\u7ba1\u652f\u67b6\u85e5\u7269\u958b\u767c\u7684\u61c9\u7528\u50f9\u503c\u3002\u7136\u800c\uff0c\u76ee\u524d\u5176\u5316\u5b78\u7d44\u6210\u8207\u4f5c\u7528\u6a5f\u5236\u5c1a\u672a\u6e05\u695a\uff0c\u662f\u672a\u4f86\u4ecd\u9700\u9032\u4e00\u6b65\u63a2\u8a0e\u7684\u7814\u7a76\u65b9\u5411\u3002\u6c23\u7403\u64f4\u5f35\u8853\uff08balloon angioplasty\uff1bBA\uff09\u662f\u4e00\u9805\u904b\u7528\u65bc\u6cbb\u7642\u6025\u6027\u52d5\u8108\u963b\u585e\uff08\u4f8b\u5982\u5fc3\u808c\u6897\u585e\uff09\u7684\u5fc3\u81df\u5167\u79d1\u624b\u8853\uff0c\u4f46\u537b\u6709\u9ad8\u6bd4\u4f8b\u7684\u60a3\u8005\u8853\u5f8c\u7522\u751f\u8840\u7ba1\u518d\u963b\u585e\uff08restenosis\uff09\u7684\u4f75\u767c\u75c7<\/p>\n 1-4<\/p>\n \u3002\u8840\u7ba1\u518d\u963b\u585e\u662f\u8840\u7ba1\u58c1\u53d7\u640d\u5f8c\u7684\u7570\u5e38\u4fee\u5fa9\u73fe\u8c61\uff0c\u5176\u6210\u56e0\u53ef\u6b78\u7d0d\u70ba\u8840\u7ba1\u5167\u819c\u589e\u751f\uff08intimal hyperplasia\uff09\u548c\u7d50\u69cb\u6027\u91cd\u6574\uff08remodeling\uff09<\/p>\n 5-8<\/p>\n \u3002\u5176\u4e2d\uff0c\u4ee5\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u6210\u56e0\u70ba\u591a\u6578\u5b78\u8005\u6240\u63a1\u7d0d\u3002\u800c\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u7684\u904e\u5ea6\u589e\u751f\u8207\u9077\u79fb\u5728\u5176\u4e2d\u626e\u6f14\u6700\u91cd\u8981\u7684\u75c5\u7406\u89d2\u8272<\/p>\n 9-10<\/p>\n \uff0c\u56e0\u6b64\u6210\u70ba\u958b\u767c\u9810\u9632\u85e5\u7269\u6216\u4fdd\u5065\u98df\u54c1\u7684\u6f5b\u5728\u8a55\u4f30\u6a19\u7684\u3002<\/p>\n \u6d77\u6d0b\u8cc7\u6e90\u8c50\u5bcc\uff0c\u800c\u6df1\u5c64\u6d77\u6c34\u76f8\u95dc\u7684\u7522\u54c1\u958b\u767c\u61c9\u7528\u66f4\u662f\u76ee\u524d\u71b1\u9580\u7684\u7814\u767c\u65b9\u5411\u3002\u9664\u5df2\u5ee3\u6cdb\u7684\u88ab\u61c9\u7528\u65bc\u8fb2\u6f01\u696d\u990a\u6b96\u3001\u5316\u599d\u54c1\u3001\u98f2\u6599\u696d\u5916\uff0c\u5728\u4fdd\u5065\u7522\u54c1\u548c\u85e5\u7269\u7684\u958b\u767c\u4ea6\u6df1\u5177\u5e02\u5834\u6f5b\u529b\u548c\u7d93\u6fdf\u50f9\u503c\u3002\u6d77\u6c34\u5bcc\u542b\u591a\u7a2e\u6709\u6a5f\u6216\u7926\u7269\u8cea\u6210\u5206\uff0c\u5176\u4e2d\u53c8\u4ee5\u9382\u96e2\u5b50\u7684\u4fdd\u5065\u529f\u6548\u6700\u88ab\u773e\u6240\u719f\u77e5\u548c\u7814\u7a76\u95dc\u6ce8\u3002\u773e\u591a\u7814\u7a76\u4ea6\u986f\u793a\uff0c\u9382\u96e2\u5b50\u5177\u6709\u6e1b\u5c11\u7f79\u60a3\u591a\u7a2e\u75be\u75c5\uff08\u4f8b\u5982\u9ad8\u8840\u58d3\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u75c7\u3001\u5fc3\u808c\u6897\u585e\u3001\u7cd6\u5c3f\u75c5\u548c\u764c\u75c7\uff09\u7684\u6f5b\u529b\u3002\u800c\u7814\u7a76\u4e5f\u8b49\u5be6\u9382\u96e2\u5b50\u5177\u6709\u6291\u5236\u4eba\u985e\u51a0\u72c0\u52d5\u8108\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u529f\u6548\uff0c\u5176\u4f5c\u7528\u6a5f\u5236\u727d\u6d89\u5305\u62ec\u7d30\u80de\u5167\u751f\u9577\u56e0\u5b50\u53ca\u5176\u63a5\u53d7\u5668\u548c\u4e0b\u6e38\u5206\u5b50\u50b3\u905e\u9014\u5f91\uff0c\u4ee5\u53ca\u7d30\u80de\u9031\u671f\u548c\u7d30\u80de\u51cb\u4ea1\u7b49\u773e\u591a\u5206\u5b50\u5728\u5167\u7684\u57fa\u56e0\u8abf\u63a7<\/p>\n 11<\/p>\n \u3002\u9019\u7d50\u679c\u66f4\u652f\u6301\u4e86\u9382\u96e2\u5b50\u5728\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u61c9\u7528\u6f5b\u529b\u3002\u540c\u6a23\u5730\uff0c\u98f2\u7528\u6df1\u5c64\u6d77\u6c34\u4e5f\u88ab\u6307\u51fa\u63d0\u4f9b\u591a\u7a2e\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u529f\u6548\u8207\u4f5c\u7528\uff0c\u5305\u62ec\u9810\u9632\u9ad8\u8840\u8102\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u548c\u9ad8\u8840\u58d3\uff0c\u4ee5\u53ca\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7b49\u529f\u6548<\/p>\n 12-14<\/p>\n \u3002<\/p>\n \u8fd1\u671f\uff0c\u6211\u5011\u91dd\u5c0d\u4e0d\u540c\u7926\u7269\u8cea\u7d44\u6210\u4e4b\u6df1\u5c64\u6d77\u6c34\u6fc3\u7e2e\u6db2\uff08DSC\uff09\u9032\u884c\u4e86\u4e00\u7cfb\u5217\u6d3b\u6027\u8a55\u4f30\uff0c\u4ee5\u77ad\u89e3\u9664\u4e86\u9382\u96e2\u5b50\u5916\uff0c\u6df1\u5c64\u6d77\u6c34\u4e2d\u662f\u5426\u5b58\u5728\u5176\u4ed6\u5177\u5099\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u6d3b\u6027\u6210\u5206\uff0c\u4ee5\u53ca\u4e0d\u540c\u7522\u54c1\u88fd\u7a0b\u5c0d\u6d3b\u6027\u7684\u5f71\u97ff\u3002\u5728\u7d30\u80de\u589e\u751f\u5be6\u9a57\uff08MTT assay\uff09\u4e2d\uff0c\u767c\u73fe\u6df1\u5c64\u6d77\u6c34\u7684\u9152\u7cbe\u8403\u53d6\u6db2\uff08DSC-DOM\uff09\u5c0d\u6291\u5236\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u6548\u679c\u6700\u986f\u8457\uff0c\u6bd4\u6b63\u5c0d\u7167\u7d44\uff08\u6c27\u5316\u9382\uff1bMgCl2<\/sub>\uff09\u6548\u679c\u66f4\u4f73\u3002\u800c\u5305\u62ec\u9ad8\u9382\u7121\u9223\u6fc3\u7e2e\u6db2\uff08DSC-DeCa\uff09\u3001\u9ad8\u9223\u9ad8\u9382\u6fc3\u7e2e\u6db2\uff08DSC-HiCa\uff09\u548c\u6e1b\u58d3\u6fc3\u7e2e\u6db2\uff08DSC-RP\uff09\u5728\u5167\u7684\u5176\u4ed6\u7d44\u5225\uff0c\u5176\u6291\u5236\u6548\u679c\u8207\u6b63\u5c0d\u7167\u7d44\u76f8\u7576\uff08<\/p>\n \u5716\uff11<\/p>\n \uff09\u3002\u800c\u7d93\u9032\u4e00\u6b65\u5206\u6790\u4e0d\u540cDSC\u5c0d\u7d30\u80de\u9031\u671f\u7684\u8abf\u63a7\u5f71\u97ff\u6307\u51fa\uff0cMgCl2<\/sub>\u4e3b\u8981\u662f\u9020\u6210\u7d30\u80de\u751f\u9577\u6291\u5236\uff08\u505c\u6eef\u65bcG0\/G1\u671f\uff09\uff0c\u4e26\u7a0d\u5177\u7d30\u80de\u51cb\u4ea1\uff08Sub-G1\u6bd4\u4f8b\u589e\u52a0\uff09\u4f5c\u7528\u3002\u800cDSC-DeCa\u5247\u4e3b\u8981\u5c0e\u81f4\u7d30\u80de\u51cb\u4ea1\uff0c\u4f46\u6709\u90e8\u5206\u4fc3\u7d30\u80de\u505c\u6eef\u7684\u6548\u679c\u3002DSC-HiCa\u53ea\u6709\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\u3002\u800cDSC-RP\u548cDSC-DOM\u5247\u540c\u6642\u5177\u5099\u6291\u5236\u7d30\u80de\u751f\u9577\u548c\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\uff08<\/p>\n \u57162<\/p>\n \uff09\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7d30\u80de\u9077\u79fb\u5206\u6790\u6cd5\uff08wound healing assay\uff09\u7684\u5be6\u9a57\u4e2d\uff0c\u5247\u986f\u793aMgCl2<\/sub>\u548c\u6240\u6709DSC\u7522\u54c1\u7686\u5177\u6709\u986f\u8457\u6291\u5236\u7d30\u80de\u9077\u79fb\u7684\u985e\u4f3c\u529f\u6548\uff08<\/p>\n \u57163<\/p>\n \uff09\u3002\u800c\u5728\u8207\u7d30\u80de\u589e\u751f\u6216\u9077\u79fb\u76f8\u95dc\u4e4b\u5206\u5b50\u9014\u5f91\uff08PI3K-AKT\u3001ERK1\/2-MAPK\u548cAMPK\uff09\u7684\u8abf\u63a7\u5f71\u97ff\u65b9\u9762\uff08<\/p>\n \u57164<\/p>\n \uff09\u3002MgCl2<\/sub>\u548c\u4e0d\u540cDSC\uff08\u9664DSC-DOM\u7d44\u5916\uff09\u7686\u53ef\u986f\u8457\u6291\u5236\u8840\u6e05\u6240\u6d3b\u5316\u7684ERK1\/2-MAPK\u5206\u5b50\u9014\u5f91\uff0c\u4ee5\u53ca\u4fc3\u4f7fAMPK\u6d3b\u5316\u3002\u800c\u6d3b\u5316AMPK\u7684\u6548\u679c\uff0c\u53c8\u4ee5DSC-HiCa\u548cDSC-RP\u7684\u4f5c\u7528\u7a81\u51fa\u3002\u4f46DSC-DOM\u5728\u6e2c\u8a66\u7684\u6fc3\u5ea6\u4e0b\uff0c\u5c0d\u6240\u6709\u8a55\u4f30\u7684\u5206\u5b50\u7686\u7121\u660e\u986f\u7684\u8abf\u63a7\u6548\u679c\u3002\u6211\u5011\u4e5f\u5229\u7528\u5927\u9f20\u9838\u52d5\u8108\u6c23\u7403\u64f4\u5f35\u8853\u7684\u6d3b\u9ad4\u8a55\u4f30\u6a21\u5f0f\u4f86\u8a55\u4f30\u4e0d\u540cDSC\u9810\u9632\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u6548\u679c\uff08<\/p>\n \u57165<\/p>\n \uff09\u3002\u7d44\u7e54\u75c5\u7406\u5b78\u7684\u5206\u6790\u4e2d\uff0c\u8ca0\u5c0d\u7167\u7d44\uff08RO\u548cEtOH\u7d44\uff1b\u6eb6\u5a92\u7d44\uff09\u7684\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u56b4\u91cd\u6027\u6307\u6a19\uff08ratio of neointima-to-media area\uff1b\uff2e\/M ratio\uff09\u505a\u70ba\u6bd4\u8f03\u7684\u57fa\u6e96\u3002\u800c\u6295\u8207MgCl2<\/sub>\u3001DSC-DeCa\u6216DSC-HiCa\u5f8c\uff0c\u5176N\/M ratio\u6709\u8f03RO\u7d44\u6e1b\u5c11\u7684\u8da8\u52e2\u3002\u800cDSC-RP\u7d44\u5247\u4f3c\u4e4e\u6c92\u6709\u986f\u8457\u6291\u5236\u6548\u679c\u3002\u7136\u800c\uff0c\u6295\u8207DSC-DOM\u5f8c\uff0c\u5176N\/M ratio\u8f03EtOH\u7d44\u4e5f\u6709\u964d\u4f4e\u7684\u8da8\u52e2\uff0c\u4e14\u5176N\/M ratio\u4e5f\u662f\u6240\u6709DSC\u7d44\u5225\u4e2d\u6700\u5c0f\u8005\u3002<\/p>\n \u7d9c\u5408\u6211\u5011\u8fd1\u671f\u7684\u5be6\u9a57\u6210\u679c\u986f\u793a\uff0c\u96d6\u7136\u4e0d\u540cDSC\u7522\u54c1\u5c0d\u65bc\u6291\u5236\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u8207\u9077\u79fb\u7684\u80fd\u529b\u76f8\u8fd1\u3002\u4f46\u82e5\u9032\u4e00\u6b65\u63a2\u8a0e\u4e0d\u540cDSC\u7522\u54c1\u5c0d\u7d30\u80de\u751f\u9577\u6216\u7d30\u80de\u9031\u671f\u76f8\u95dc\u5206\u5b50\u7684\u8abf\u63a7\u5dee\u7570\uff0c\u5247\u6703\u767c\u73fe\u5176\u8abf\u63a7\u6a5f\u5236\u6216\u4f5c\u7528\u5f37\u5ea6\u4e26\u4e0d\u76f8\u540c\u3002\u9019\u4e9b\u5dee\u7570\u986f\u793a\u88fd\u7a0b\u53c3\u6578\u7684\u6539\u8b8a\uff08\u4f8b\u5982\u6eab\u5ea6\u6216\u812b\u9e7d\u65b9\u6cd5\uff09\u78ba\u5be6\u6703\u5f71\u97ffDSC\u7684\u5fc3\u8840\u7ba1\u4fdd\u8b77\u4f5c\u7528\uff0c\u800c\u5176\u4e2d\u53ef\u80fd\u539f\u56e0\u5305\u62ec\u7121\u6a5f\u96e2\u5b50\u6216\u6709\u6a5f\u7269\u6d3b\u6027\u6210\u5206\u7684\u6bd4\u4f8b\u8b8a\u5316\u6216\u71b1\u5931\u6d3b\u3002\u7d9c\u5408\u76f8\u95dc\u5be6\u9a57\u6578\u64da\uff0c\u4ee5\u6295\u8207DSC-DOM\u7684\u6291\u5236\u6548\u679c\u6700\u70ba\u986f\u8457\uff0c\u4e5f\u6df1\u5177\u505a\u70ba\u8840\u7ba1\u652f\u67b6\u85e5\u7269\u958b\u767c\u7684\u61c9\u7528\u50f9\u503c\u3002\u7136\u800c\uff0c\u76ee\u524d\u5176\u5316\u5b78\u7d44\u6210\u8207\u4f5c\u7528\u6a5f\u5236\u5c1a\u672a\u6e05\u695a\uff0c\u662f\u672a\u4f86\u4ecd\u9700\u9032\u4e00\u6b65\u63a2\u8a0e\u7684\u7814\u7a76\u65b9\u5411\u3002\u6c23\u7403\u64f4\u5f35\u8853\uff08balloon angioplasty\uff1bBA\uff09\u662f\u4e00\u9805\u904b\u7528\u65bc\u6cbb\u7642\u6025\u6027\u52d5\u8108\u963b\u585e\uff08\u4f8b\u5982\u5fc3\u808c\u6897\u585e\uff09\u7684\u5fc3\u81df\u5167\u79d1\u624b\u8853\uff0c\u4f46\u537b\u6709\u9ad8\u6bd4\u4f8b\u7684\u60a3\u8005\u8853\u5f8c\u7522\u751f\u8840\u7ba1\u518d\u963b\u585e\uff08restenosis\uff09\u7684\u4f75\u767c\u75c7<\/p>\n 1-4<\/p>\n \u3002\u8840\u7ba1\u518d\u963b\u585e\u662f\u8840\u7ba1\u58c1\u53d7\u640d\u5f8c\u7684\u7570\u5e38\u4fee\u5fa9\u73fe\u8c61\uff0c\u5176\u6210\u56e0\u53ef\u6b78\u7d0d\u70ba\u8840\u7ba1\u5167\u819c\u589e\u751f\uff08intimal hyperplasia\uff09\u548c\u7d50\u69cb\u6027\u91cd\u6574\uff08remodeling\uff09<\/p>\n 5-8<\/p>\n \u3002\u5176\u4e2d\uff0c\u4ee5\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u6210\u56e0\u70ba\u591a\u6578\u5b78\u8005\u6240\u63a1\u7d0d\u3002\u800c\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u7684\u904e\u5ea6\u589e\u751f\u8207\u9077\u79fb\u5728\u5176\u4e2d\u626e\u6f14\u6700\u91cd\u8981\u7684\u75c5\u7406\u89d2\u8272<\/p>\n 9-10<\/p>\n \uff0c\u56e0\u6b64\u6210\u70ba\u958b\u767c\u9810\u9632\u85e5\u7269\u6216\u4fdd\u5065\u98df\u54c1\u7684\u6f5b\u5728\u8a55\u4f30\u6a19\u7684\u3002<\/p>\n \u6d77\u6d0b\u8cc7\u6e90\u8c50\u5bcc\uff0c\u800c\u6df1\u5c64\u6d77\u6c34\u76f8\u95dc\u7684\u7522\u54c1\u958b\u767c\u61c9\u7528\u66f4\u662f\u76ee\u524d\u71b1\u9580\u7684\u7814\u767c\u65b9\u5411\u3002\u9664\u5df2\u5ee3\u6cdb\u7684\u88ab\u61c9\u7528\u65bc\u8fb2\u6f01\u696d\u990a\u6b96\u3001\u5316\u599d\u54c1\u3001\u98f2\u6599\u696d\u5916\uff0c\u5728\u4fdd\u5065\u7522\u54c1\u548c\u85e5\u7269\u7684\u958b\u767c\u4ea6\u6df1\u5177\u5e02\u5834\u6f5b\u529b\u548c\u7d93\u6fdf\u50f9\u503c\u3002\u6d77\u6c34\u5bcc\u542b\u591a\u7a2e\u6709\u6a5f\u6216\u7926\u7269\u8cea\u6210\u5206\uff0c\u5176\u4e2d\u53c8\u4ee5\u9382\u96e2\u5b50\u7684\u4fdd\u5065\u529f\u6548\u6700\u88ab\u773e\u6240\u719f\u77e5\u548c\u7814\u7a76\u95dc\u6ce8\u3002\u773e\u591a\u7814\u7a76\u4ea6\u986f\u793a\uff0c\u9382\u96e2\u5b50\u5177\u6709\u6e1b\u5c11\u7f79\u60a3\u591a\u7a2e\u75be\u75c5\uff08\u4f8b\u5982\u9ad8\u8840\u58d3\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u75c7\u3001\u5fc3\u808c\u6897\u585e\u3001\u7cd6\u5c3f\u75c5\u548c\u764c\u75c7\uff09\u7684\u6f5b\u529b\u3002\u800c\u7814\u7a76\u4e5f\u8b49\u5be6\u9382\u96e2\u5b50\u5177\u6709\u6291\u5236\u4eba\u985e\u51a0\u72c0\u52d5\u8108\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u529f\u6548\uff0c\u5176\u4f5c\u7528\u6a5f\u5236\u727d\u6d89\u5305\u62ec\u7d30\u80de\u5167\u751f\u9577\u56e0\u5b50\u53ca\u5176\u63a5\u53d7\u5668\u548c\u4e0b\u6e38\u5206\u5b50\u50b3\u905e\u9014\u5f91\uff0c\u4ee5\u53ca\u7d30\u80de\u9031\u671f\u548c\u7d30\u80de\u51cb\u4ea1\u7b49\u773e\u591a\u5206\u5b50\u5728\u5167\u7684\u57fa\u56e0\u8abf\u63a7<\/p>\n 11<\/p>\n \u3002\u9019\u7d50\u679c\u66f4\u652f\u6301\u4e86\u9382\u96e2\u5b50\u5728\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u61c9\u7528\u6f5b\u529b\u3002\u540c\u6a23\u5730\uff0c\u98f2\u7528\u6df1\u5c64\u6d77\u6c34\u4e5f\u88ab\u6307\u51fa\u63d0\u4f9b\u591a\u7a2e\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u529f\u6548\u8207\u4f5c\u7528\uff0c\u5305\u62ec\u9810\u9632\u9ad8\u8840\u8102\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u548c\u9ad8\u8840\u58d3\uff0c\u4ee5\u53ca\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7b49\u529f\u6548<\/p>\n 12-14<\/p>\n \u3002<\/p>\n \u8fd1\u671f\uff0c\u6211\u5011\u91dd\u5c0d\u4e0d\u540c\u7926\u7269\u8cea\u7d44\u6210\u4e4b\u6df1\u5c64\u6d77\u6c34\u6fc3\u7e2e\u6db2\uff08DSC\uff09\u9032\u884c\u4e86\u4e00\u7cfb\u5217\u6d3b\u6027\u8a55\u4f30\uff0c\u4ee5\u77ad\u89e3\u9664\u4e86\u9382\u96e2\u5b50\u5916\uff0c\u6df1\u5c64\u6d77\u6c34\u4e2d\u662f\u5426\u5b58\u5728\u5176\u4ed6\u5177\u5099\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u6d3b\u6027\u6210\u5206\uff0c\u4ee5\u53ca\u4e0d\u540c\u7522\u54c1\u88fd\u7a0b\u5c0d\u6d3b\u6027\u7684\u5f71\u97ff\u3002\u5728\u7d30\u80de\u589e\u751f\u5be6\u9a57\uff08MTT assay\uff09\u4e2d\uff0c\u767c\u73fe\u6df1\u5c64\u6d77\u6c34\u7684\u9152\u7cbe\u8403\u53d6\u6db2\uff08DSC-DOM\uff09\u5c0d\u6291\u5236\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u6548\u679c\u6700\u986f\u8457\uff0c\u6bd4\u6b63\u5c0d\u7167\u7d44\uff08\u6c27\u5316\u9382\uff1bMgCl2<\/sub>\uff09\u6548\u679c\u66f4\u4f73\u3002\u800c\u5305\u62ec\u9ad8\u9382\u7121\u9223\u6fc3\u7e2e\u6db2\uff08DSC-DeCa\uff09\u3001\u9ad8\u9223\u9ad8\u9382\u6fc3\u7e2e\u6db2\uff08DSC-HiCa\uff09\u548c\u6e1b\u58d3\u6fc3\u7e2e\u6db2\uff08DSC-RP\uff09\u5728\u5167\u7684\u5176\u4ed6\u7d44\u5225\uff0c\u5176\u6291\u5236\u6548\u679c\u8207\u6b63\u5c0d\u7167\u7d44\u76f8\u7576\uff08<\/p>\n \u5716\uff11<\/p>\n \uff09\u3002\u800c\u7d93\u9032\u4e00\u6b65\u5206\u6790\u4e0d\u540cDSC\u5c0d\u7d30\u80de\u9031\u671f\u7684\u8abf\u63a7\u5f71\u97ff\u6307\u51fa\uff0cMgCl2<\/sub>\u4e3b\u8981\u662f\u9020\u6210\u7d30\u80de\u751f\u9577\u6291\u5236\uff08\u505c\u6eef\u65bcG0\/G1\u671f\uff09\uff0c\u4e26\u7a0d\u5177\u7d30\u80de\u51cb\u4ea1\uff08Sub-G1\u6bd4\u4f8b\u589e\u52a0\uff09\u4f5c\u7528\u3002\u800cDSC-DeCa\u5247\u4e3b\u8981\u5c0e\u81f4\u7d30\u80de\u51cb\u4ea1\uff0c\u4f46\u6709\u90e8\u5206\u4fc3\u7d30\u80de\u505c\u6eef\u7684\u6548\u679c\u3002DSC-HiCa\u53ea\u6709\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\u3002\u800cDSC-RP\u548cDSC-DOM\u5247\u540c\u6642\u5177\u5099\u6291\u5236\u7d30\u80de\u751f\u9577\u548c\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\uff08<\/p>\n \u57162<\/p>\n \uff09\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7d30\u80de\u9077\u79fb\u5206\u6790\u6cd5\uff08wound healing assay\uff09\u7684\u5be6\u9a57\u4e2d\uff0c\u5247\u986f\u793aMgCl2<\/sub>\u548c\u6240\u6709DSC\u7522\u54c1\u7686\u5177\u6709\u986f\u8457\u6291\u5236\u7d30\u80de\u9077\u79fb\u7684\u985e\u4f3c\u529f\u6548\uff08<\/p>\n \u57163<\/p>\n \uff09\u3002\u800c\u5728\u8207\u7d30\u80de\u589e\u751f\u6216\u9077\u79fb\u76f8\u95dc\u4e4b\u5206\u5b50\u9014\u5f91\uff08PI3K-AKT\u3001ERK1\/2-MAPK\u548cAMPK\uff09\u7684\u8abf\u63a7\u5f71\u97ff\u65b9\u9762\uff08<\/p>\n \u57164<\/p>\n \uff09\u3002MgCl2<\/sub>\u548c\u4e0d\u540cDSC\uff08\u9664DSC-DOM\u7d44\u5916\uff09\u7686\u53ef\u986f\u8457\u6291\u5236\u8840\u6e05\u6240\u6d3b\u5316\u7684ERK1\/2-MAPK\u5206\u5b50\u9014\u5f91\uff0c\u4ee5\u53ca\u4fc3\u4f7fAMPK\u6d3b\u5316\u3002\u800c\u6d3b\u5316AMPK\u7684\u6548\u679c\uff0c\u53c8\u4ee5DSC-HiCa\u548cDSC-RP\u7684\u4f5c\u7528\u7a81\u51fa\u3002\u4f46DSC-DOM\u5728\u6e2c\u8a66\u7684\u6fc3\u5ea6\u4e0b\uff0c\u5c0d\u6240\u6709\u8a55\u4f30\u7684\u5206\u5b50\u7686\u7121\u660e\u986f\u7684\u8abf\u63a7\u6548\u679c\u3002\u6211\u5011\u4e5f\u5229\u7528\u5927\u9f20\u9838\u52d5\u8108\u6c23\u7403\u64f4\u5f35\u8853\u7684\u6d3b\u9ad4\u8a55\u4f30\u6a21\u5f0f\u4f86\u8a55\u4f30\u4e0d\u540cDSC\u9810\u9632\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u6548\u679c\uff08<\/p>\n \u57165<\/p>\n \uff09\u3002\u7d44\u7e54\u75c5\u7406\u5b78\u7684\u5206\u6790\u4e2d\uff0c\u8ca0\u5c0d\u7167\u7d44\uff08RO\u548cEtOH\u7d44\uff1b\u6eb6\u5a92\u7d44\uff09\u7684\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u56b4\u91cd\u6027\u6307\u6a19\uff08ratio of neointima-to-media area\uff1b\uff2e\/M ratio\uff09\u505a\u70ba\u6bd4\u8f03\u7684\u57fa\u6e96\u3002\u800c\u6295\u8207MgCl2<\/sub>\u3001DSC-DeCa\u6216DSC-HiCa\u5f8c\uff0c\u5176N\/M ratio\u6709\u8f03RO\u7d44\u6e1b\u5c11\u7684\u8da8\u52e2\u3002\u800cDSC-RP\u7d44\u5247\u4f3c\u4e4e\u6c92\u6709\u986f\u8457\u6291\u5236\u6548\u679c\u3002\u7136\u800c\uff0c\u6295\u8207DSC-DOM\u5f8c\uff0c\u5176N\/M ratio\u8f03EtOH\u7d44\u4e5f\u6709\u964d\u4f4e\u7684\u8da8\u52e2\uff0c\u4e14\u5176N\/M ratio\u4e5f\u662f\u6240\u6709DSC\u7d44\u5225\u4e2d\u6700\u5c0f\u8005\u3002<\/p>\n \u7d9c\u5408\u6211\u5011\u8fd1\u671f\u7684\u5be6\u9a57\u6210\u679c\u986f\u793a\uff0c\u96d6\u7136\u4e0d\u540cDSC\u7522\u54c1\u5c0d\u65bc\u6291\u5236\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u8207\u9077\u79fb\u7684\u80fd\u529b\u76f8\u8fd1\u3002\u4f46\u82e5\u9032\u4e00\u6b65\u63a2\u8a0e\u4e0d\u540cDSC\u7522\u54c1\u5c0d\u7d30\u80de\u751f\u9577\u6216\u7d30\u80de\u9031\u671f\u76f8\u95dc\u5206\u5b50\u7684\u8abf\u63a7\u5dee\u7570\uff0c\u5247\u6703\u767c\u73fe\u5176\u8abf\u63a7\u6a5f\u5236\u6216\u4f5c\u7528\u5f37\u5ea6\u4e26\u4e0d\u76f8\u540c\u3002\u9019\u4e9b\u5dee\u7570\u986f\u793a\u88fd\u7a0b\u53c3\u6578\u7684\u6539\u8b8a\uff08\u4f8b\u5982\u6eab\u5ea6\u6216\u812b\u9e7d\u65b9\u6cd5\uff09\u78ba\u5be6\u6703\u5f71\u97ffDSC\u7684\u5fc3\u8840\u7ba1\u4fdd\u8b77\u4f5c\u7528\uff0c\u800c\u5176\u4e2d\u53ef\u80fd\u539f\u56e0\u5305\u62ec\u7121\u6a5f\u96e2\u5b50\u6216\u6709\u6a5f\u7269\u6d3b\u6027\u6210\u5206\u7684\u6bd4\u4f8b\u8b8a\u5316\u6216\u71b1\u5931\u6d3b\u3002\u7d9c\u5408\u76f8\u95dc\u5be6\u9a57\u6578\u64da\uff0c\u4ee5\u6295\u8207DSC-DOM\u7684\u6291\u5236\u6548\u679c\u6700\u70ba\u986f\u8457\uff0c\u4e5f\u6df1\u5177\u505a\u70ba\u8840\u7ba1\u652f\u67b6\u85e5\u7269\u958b\u767c\u7684\u61c9\u7528\u50f9\u503c\u3002\u7136\u800c\uff0c\u76ee\u524d\u5176\u5316\u5b78\u7d44\u6210\u8207\u4f5c\u7528\u6a5f\u5236\u5c1a\u672a\u6e05\u695a\uff0c\u662f\u672a\u4f86\u4ecd\u9700\u9032\u4e00\u6b65\u63a2\u8a0e\u7684\u7814\u7a76\u65b9\u5411\u3002\u6c23\u7403\u64f4\u5f35\u8853\uff08balloon angioplasty\uff1bBA\uff09\u662f\u4e00\u9805\u904b\u7528\u65bc\u6cbb\u7642\u6025\u6027\u52d5\u8108\u963b\u585e\uff08\u4f8b\u5982\u5fc3\u808c\u6897\u585e\uff09\u7684\u5fc3\u81df\u5167\u79d1\u624b\u8853\uff0c\u4f46\u537b\u6709\u9ad8\u6bd4\u4f8b\u7684\u60a3\u8005\u8853\u5f8c\u7522\u751f\u8840\u7ba1\u518d\u963b\u585e\uff08restenosis\uff09\u7684\u4f75\u767c\u75c7<\/p>\n 1-4<\/p>\n \u3002\u8840\u7ba1\u518d\u963b\u585e\u662f\u8840\u7ba1\u58c1\u53d7\u640d\u5f8c\u7684\u7570\u5e38\u4fee\u5fa9\u73fe\u8c61\uff0c\u5176\u6210\u56e0\u53ef\u6b78\u7d0d\u70ba\u8840\u7ba1\u5167\u819c\u589e\u751f\uff08intimal hyperplasia\uff09\u548c\u7d50\u69cb\u6027\u91cd\u6574\uff08remodeling\uff09<\/p>\n 5-8<\/p>\n \u3002\u5176\u4e2d\uff0c\u4ee5\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u6210\u56e0\u70ba\u591a\u6578\u5b78\u8005\u6240\u63a1\u7d0d\u3002\u800c\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u7684\u904e\u5ea6\u589e\u751f\u8207\u9077\u79fb\u5728\u5176\u4e2d\u626e\u6f14\u6700\u91cd\u8981\u7684\u75c5\u7406\u89d2\u8272<\/p>\n 9-10<\/p>\n \uff0c\u56e0\u6b64\u6210\u70ba\u958b\u767c\u9810\u9632\u85e5\u7269\u6216\u4fdd\u5065\u98df\u54c1\u7684\u6f5b\u5728\u8a55\u4f30\u6a19\u7684\u3002<\/p>\n \u6d77\u6d0b\u8cc7\u6e90\u8c50\u5bcc\uff0c\u800c\u6df1\u5c64\u6d77\u6c34\u76f8\u95dc\u7684\u7522\u54c1\u958b\u767c\u61c9\u7528\u66f4\u662f\u76ee\u524d\u71b1\u9580\u7684\u7814\u767c\u65b9\u5411\u3002\u9664\u5df2\u5ee3\u6cdb\u7684\u88ab\u61c9\u7528\u65bc\u8fb2\u6f01\u696d\u990a\u6b96\u3001\u5316\u599d\u54c1\u3001\u98f2\u6599\u696d\u5916\uff0c\u5728\u4fdd\u5065\u7522\u54c1\u548c\u85e5\u7269\u7684\u958b\u767c\u4ea6\u6df1\u5177\u5e02\u5834\u6f5b\u529b\u548c\u7d93\u6fdf\u50f9\u503c\u3002\u6d77\u6c34\u5bcc\u542b\u591a\u7a2e\u6709\u6a5f\u6216\u7926\u7269\u8cea\u6210\u5206\uff0c\u5176\u4e2d\u53c8\u4ee5\u9382\u96e2\u5b50\u7684\u4fdd\u5065\u529f\u6548\u6700\u88ab\u773e\u6240\u719f\u77e5\u548c\u7814\u7a76\u95dc\u6ce8\u3002\u773e\u591a\u7814\u7a76\u4ea6\u986f\u793a\uff0c\u9382\u96e2\u5b50\u5177\u6709\u6e1b\u5c11\u7f79\u60a3\u591a\u7a2e\u75be\u75c5\uff08\u4f8b\u5982\u9ad8\u8840\u58d3\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u75c7\u3001\u5fc3\u808c\u6897\u585e\u3001\u7cd6\u5c3f\u75c5\u548c\u764c\u75c7\uff09\u7684\u6f5b\u529b\u3002\u800c\u7814\u7a76\u4e5f\u8b49\u5be6\u9382\u96e2\u5b50\u5177\u6709\u6291\u5236\u4eba\u985e\u51a0\u72c0\u52d5\u8108\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u529f\u6548\uff0c\u5176\u4f5c\u7528\u6a5f\u5236\u727d\u6d89\u5305\u62ec\u7d30\u80de\u5167\u751f\u9577\u56e0\u5b50\u53ca\u5176\u63a5\u53d7\u5668\u548c\u4e0b\u6e38\u5206\u5b50\u50b3\u905e\u9014\u5f91\uff0c\u4ee5\u53ca\u7d30\u80de\u9031\u671f\u548c\u7d30\u80de\u51cb\u4ea1\u7b49\u773e\u591a\u5206\u5b50\u5728\u5167\u7684\u57fa\u56e0\u8abf\u63a7<\/p>\n 11<\/p>\n \u3002\u9019\u7d50\u679c\u66f4\u652f\u6301\u4e86\u9382\u96e2\u5b50\u5728\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u61c9\u7528\u6f5b\u529b\u3002\u540c\u6a23\u5730\uff0c\u98f2\u7528\u6df1\u5c64\u6d77\u6c34\u4e5f\u88ab\u6307\u51fa\u63d0\u4f9b\u591a\u7a2e\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u529f\u6548\u8207\u4f5c\u7528\uff0c\u5305\u62ec\u9810\u9632\u9ad8\u8840\u8102\u3001\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u548c\u9ad8\u8840\u58d3\uff0c\u4ee5\u53ca\u6291\u5236\u8840\u7ba1\u5167\u819c\u589e\u751f\u7b49\u529f\u6548<\/p>\n 12-14<\/p>\n \u3002<\/p>\n \u8fd1\u671f\uff0c\u6211\u5011\u91dd\u5c0d\u4e0d\u540c\u7926\u7269\u8cea\u7d44\u6210\u4e4b\u6df1\u5c64\u6d77\u6c34\u6fc3\u7e2e\u6db2\uff08DSC\uff09\u9032\u884c\u4e86\u4e00\u7cfb\u5217\u6d3b\u6027\u8a55\u4f30\uff0c\u4ee5\u77ad\u89e3\u9664\u4e86\u9382\u96e2\u5b50\u5916\uff0c\u6df1\u5c64\u6d77\u6c34\u4e2d\u662f\u5426\u5b58\u5728\u5176\u4ed6\u5177\u5099\u5fc3\u8840\u7ba1\u4fdd\u8b77\u7684\u6d3b\u6027\u6210\u5206\uff0c\u4ee5\u53ca\u4e0d\u540c\u7522\u54c1\u88fd\u7a0b\u5c0d\u6d3b\u6027\u7684\u5f71\u97ff\u3002\u5728\u7d30\u80de\u589e\u751f\u5be6\u9a57\uff08MTT assay\uff09\u4e2d\uff0c\u767c\u73fe\u6df1\u5c64\u6d77\u6c34\u7684\u9152\u7cbe\u8403\u53d6\u6db2\uff08DSC-DOM\uff09\u5c0d\u6291\u5236\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u589e\u751f\u7684\u6548\u679c\u6700\u986f\u8457\uff0c\u6bd4\u6b63\u5c0d\u7167\u7d44\uff08\u6c27\u5316\u9382\uff1bMgCl2<\/sub>\uff09\u6548\u679c\u66f4\u4f73\u3002\u800c\u5305\u62ec\u9ad8\u9382\u7121\u9223\u6fc3\u7e2e\u6db2\uff08DSC-DeCa\uff09\u3001\u9ad8\u9223\u9ad8\u9382\u6fc3\u7e2e\u6db2\uff08DSC-HiCa\uff09\u548c\u6e1b\u58d3\u6fc3\u7e2e\u6db2\uff08DSC-RP\uff09\u5728\u5167\u7684\u5176\u4ed6\u7d44\u5225\uff0c\u5176\u6291\u5236\u6548\u679c\u8207\u6b63\u5c0d\u7167\u7d44\u76f8\u7576\uff08<\/p>\n \u5716\uff11<\/p>\n \uff09\u3002\u800c\u7d93\u9032\u4e00\u6b65\u5206\u6790\u4e0d\u540cDSC\u5c0d\u7d30\u80de\u9031\u671f\u7684\u8abf\u63a7\u5f71\u97ff\u6307\u51fa\uff0cMgCl2<\/sub>\u4e3b\u8981\u662f\u9020\u6210\u7d30\u80de\u751f\u9577\u6291\u5236\uff08\u505c\u6eef\u65bcG0\/G1\u671f\uff09\uff0c\u4e26\u7a0d\u5177\u7d30\u80de\u51cb\u4ea1\uff08Sub-G1\u6bd4\u4f8b\u589e\u52a0\uff09\u4f5c\u7528\u3002\u800cDSC-DeCa\u5247\u4e3b\u8981\u5c0e\u81f4\u7d30\u80de\u51cb\u4ea1\uff0c\u4f46\u6709\u90e8\u5206\u4fc3\u7d30\u80de\u505c\u6eef\u7684\u6548\u679c\u3002DSC-HiCa\u53ea\u6709\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\u3002\u800cDSC-RP\u548cDSC-DOM\u5247\u540c\u6642\u5177\u5099\u6291\u5236\u7d30\u80de\u751f\u9577\u548c\u4fc3\u9032\u7d30\u80de\u51cb\u4ea1\u7684\u80fd\u529b\uff08<\/p>\n \u57162<\/p>\n \uff09\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7d30\u80de\u9077\u79fb\u5206\u6790\u6cd5\uff08wound healing assay\uff09\u7684\u5be6\u9a57\u4e2d\uff0c\u5247\u986f\u793aMgCl2<\/sub>\u548c\u6240\u6709DSC\u7522\u54c1\u7686\u5177\u6709\u986f\u8457\u6291\u5236\u7d30\u80de\u9077\u79fb\u7684\u985e\u4f3c\u529f\u6548\uff08<\/p>\n \u57163<\/p>\n \uff09\u3002\u800c\u5728\u8207\u7d30\u80de\u589e\u751f\u6216\u9077\u79fb\u76f8\u95dc\u4e4b\u5206\u5b50\u9014\u5f91\uff08PI3K-AKT\u3001ERK1\/2-MAPK\u548cAMPK\uff09\u7684\u8abf\u63a7\u5f71\u97ff\u65b9\u9762\uff08<\/p>\n \u57164<\/p>\n \uff09\u3002MgCl2<\/sub>\u548c\u4e0d\u540cDSC\uff08\u9664DSC-DOM\u7d44\u5916\uff09\u7686\u53ef\u986f\u8457\u6291\u5236\u8840\u6e05\u6240\u6d3b\u5316\u7684ERK1\/2-MAPK\u5206\u5b50\u9014\u5f91\uff0c\u4ee5\u53ca\u4fc3\u4f7fAMPK\u6d3b\u5316\u3002\u800c\u6d3b\u5316AMPK\u7684\u6548\u679c\uff0c\u53c8\u4ee5DSC-HiCa\u548cDSC-RP\u7684\u4f5c\u7528\u7a81\u51fa\u3002\u4f46DSC-DOM\u5728\u6e2c\u8a66\u7684\u6fc3\u5ea6\u4e0b\uff0c\u5c0d\u6240\u6709\u8a55\u4f30\u7684\u5206\u5b50\u7686\u7121\u660e\u986f\u7684\u8abf\u63a7\u6548\u679c\u3002\u6211\u5011\u4e5f\u5229\u7528\u5927\u9f20\u9838\u52d5\u8108\u6c23\u7403\u64f4\u5f35\u8853\u7684\u6d3b\u9ad4\u8a55\u4f30\u6a21\u5f0f\u4f86\u8a55\u4f30\u4e0d\u540cDSC\u9810\u9632\u8840\u7ba1\u5167\u819c\u589e\u751f\u7684\u6548\u679c\uff08<\/p>\n \u57165<\/p>\n 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