\u8102\u80aa\u809d\u662f\u6307\u809d\u8102\u80aa\u542b\uf97e\u8d85\u904e\u5168\u809d\u81df\u91cd\u91cf\u7684\u767e\u5206\u4e4b\u4e94\uff0c\u6216\u662f\u5728\u809d\u7d44\u7e54\u5207\u7247\u4e2d\u8d85\u904e\u767e\u5206\u4e4b\u5341\u4ee5\u4e0a\u7684\u809d\u7d30\u80de\u5448\u73fe\u8102\u80aa\u7a7a\u6ce1\u8b8a\u6027\u7684\u73fe\u8c61\u800c\u7a31\u4e4b (Brunt 2001)\uff0c\u5176\u4e2d\u6700\u5e38\u898b\u75c5\u56e0\u70ba\u80a5\u80d6\u3001\u9157\u9152\u3001\u7cd6\uf9bd\u75c5\u63a7\u5236\u4e0d\u4f73\u3001\u8840\u8102\u80aa\u904e\u9ad8\u3001\u9ad4\u91cd\u904e\u91cd\u7b49\u56e0\u7d20\u9020\u6210\u8102\u80aa\u5728\u809d\u7d30\u80de\u4e2d\u7a4d\u805a (Bedogni and Bellentani 2004)\u3002\u8102\u80aa\u809d\u53c8\u53ef\u4ee5\u5206\u70ba\u9152\u7cbe\u6027\u8102\u80aa\u809d (Alcoholic Fatty liver) \u8207\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d (Non-alcoholic Fatty liver, NAFLD)\u3002\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u76ee\u524d\u662f\u767c\u5c55\u4e2d\u4e16\u754c\u6700\u5e38\u898b\u7684\u809d\u75be\u75c5\uff0c\u5f71\u97ff\u9ad8\u9054\u4e09\u5206\u4e4b\u4e00\u7684\u4eba\u53e3\u3002\u98f2\u98df\u7fd2\u6163\u53ef\u80fd\u76f4\u63a5\u4fc3\u9032\u8102\u80aa\u809d\u708e\u7d93\u7531\u8abf\u7bc0\u809d\u81df\u4e09\u9178\u7518\u6cb9\u916f\u7684\u7a4d\u805a\u53ca\u6297\u6c27\u5316\u9175\u7d20\u4e5f\u53ef\u76f4\u63a5\u5f71\u97ff\u80f0\u5cf6\u7d20\u7684\u654f\u611f\u6027\u53ca\u98ef\u5f8c\u4e09\u9178\u7518\u6cb9\u916f\u7684\u4ee3\u8b1d (Musso, Gambino et al. 2003)\u3002\u80a5\u80d6\u4f34\u96a8\u8457\u8102\u80aa\u809d\u7684\u51fa\u73fe\u9996\u5ea6\u88ab Westwater \u53ca Fainer \u63d0\u51fa (Westwater and Fainer 1958)\uff0c\u98f2\u98df\u4e5f\u53ef\u80fd\u6703\u5f71\u97ff\u809d\u81df\u8102\u80aa\u809d\u708e\uff0c\u7814\u7a76\u6307\u51fa\u98f2\u98df\u4e2d\u5bcc\u542b\u98fd\u548c\u8102\u80aa\u9178\u6703\u589e\u52a0\u809d\u81df\u8102\u8cea\u53ca\u8840\u6f3f\u80f0\u5cf6\u7d20\u6fc3\u5ea6\u800c\u5f15\u8d77\u80f0\u5cf6\u7d20\u963b\u6297 (McClain, Mokshagundam et al. 2004)\uff0c\u800c\u5728NAFLD\u75c5\u4eba\u8eab\u4e0a\u767c\u73fe\uff0c\u5927\u91cf\u651d\u53d6\u98fd\u548c\u8102\u80aa\u53ca\u81bd\u56fa\u9187\u4e26\u964d\u4f4e\u591a\u5143\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u7684\u651d\u53d6\uff0c\u9019\u7a2e\u98f2\u98df\u7fd2\u6163\u6703\u900f\u904e\u5f71\u97ff\u9910\u5f8c\u4e09\u9178\u7518\u6cb9\u916f\u7684\u4ee3\u8b1d\u53ca\u80f0\u5cf6\u7d20\u7684\u654f\u611f\u6027\u800c \u9020\u6210\u8102\u80aa\u809d\u708e\u53ca\u809d\u81df\u7684\u6c27\u5316\u50b7\u5bb3\u6216\u8005\u5927\u91cf\u651d\u53d6\u8102\u8cea\u8207\u679c\u7cd6\uff0c\u6703\u589e\u52a0\u6e38\u96e2\u8102\u80aa\u9178\u7684\u5408\u6210\u800c\u9020\u6210\u8102\u8cea\u7a4d\u805a\u5728\u809d\u81df\u4fc3\u9032\u809d\u81df\u767c\u708e\u6709\u95dc (Musso et al., 2003)\u3002\u7531\u8fd1\u5e74\u4f86\u5927\u91cf\u7684\u81e8\u5e8a\u53ca\u52d5\u7269\u5be6\u9a57\u7814\u7a76\u6240\u5f97\u7684\u5047\u8aaa\uff0c\u5f97\u77e5\u6c27\u5316\u58d3\u529b (oxidative stress)\u3001\u80f0\u5cf6\u7d20\u6297\u6027 (insulin resistence\uff0cIR) \u4ee5\u53ca\u8102\u8cea\u904e\u6c27\u5316\u4f5c\u7528 (lipid peroxidation) \u6703\u76f4\u63a5\u6216\u9593\u63a5\u5c0d\u809d\u7d30\u80de\u9032\u884c\u653b\u64ca\uff0c\u4e26\u5c0e\u81f4\u809d\u81df\u767c\u751f\u7030\u6f2b\u6027\u8102\u80aa\u6d78\u6f64\u3001\u708e\u75c7\u53cd\u61c9\u3001\u58de\u6b7b\u3001\u51cb\u4ea1\u3001\u518d\u751f\u640d\u5bb3\u4ee5\u53ca\u809d\u661f\u72c0\u7d30\u80de\u6d3b\u5316\u7b49\u4e00\u7cfb\u5217\u75c5\u7406\u9023\u9396\u6027\u514d\u75ab\u653b\u64ca\u53cd\u61c9 (Sanyal, Campbell-Sargent et al. 2001)\u3002<\/p>\n
\u6df1\u5c64\u6d77\u6c34 (deep ocean water, DOW) \u70ba\u6d77\u5e73\u9762 200 \u516c\u5c3a\u4ee5\u4e0b\u967d\u5149\u7121\u6cd5\u9032\u5165\uff0c\u5177\u4f4e\u6eab\u3001\u5bcc\u542b\u7926\u7269\u8cea\u548c\u7121\u6a5f\u71df\u990a\u9e7d\u7b49\u7279\u9ede\u4e4b\u6d77\u6c34\u3002\u7531\u65bc\u6df1\u5c64\u6d77\u6c34\u5bcc\u542b\u7926\u7269\u8cea\u9382\u3001\u9223\u3001\u9240\u3001\u92c5\u7b49\uff0c\u76ee\u524d\u53f0\u7063\u3001\u65e5\u672c\u3001\u97d3\u570b\u8207\u7f8e\u570b\u5df2\u5c07\u6df1\u5c64\u6d77\u6c34\u61c9\u7528\u65bc\u98df\u54c1\u3001\u8fb2\u696d\u3001\u5316\u599d\u54c1\u53ca\u91ab\u7642\u9818\u57df\u3002DOW \u7531\u65bc\u967d\u5149\u7121\u6cd5\u5c04\u5165\uff0c\u4e14 DOW\u4e0d\u53d7\u8868\u5c64\u6d0b\u6d41\u64fe\u52d5\uff0c\u7121\u6cd5\u8207\u8868\u5c64\u6eab\u6696\u6d77\u6c34\u6df7\u5408\uff0c\u6240\u4ee5\u5177\u4f4e\u6eab\u7279\u6027\uff0c\u800c\u5149\u7dda\u7121\u6cd5\u5230\u9054\uff0c\u5149\u5408\u4f5c\u7528\u578b\u6d6e\u6e38\u751f\u7269\u7121\u6cd5\u9032\u884c\u5149\u5408\u4f5c\u7528\uff0c\u6d6e\u6e38\u751f\u7269\u56e0\u6b64\u8655\u65bc\u4f11\u7720\u72c0\u614b\u7121\u6cd5\u7522\u751f\u6709\u6a5f\u7269\u8cea\uff0c\u4ee5\u53ca\u7d30\u83cc\u7531\u65bc\u74b0\u5883\u4e2d\u6709\u6a5f\u7269\u8cea\u542b\u91cf\u904e\u5c11\uff0c\u5c0e\u81f4\u7d30\u83cc\u7121\u6cd5\u5927\u91cf\u7e41\u6b96\uff0c\u6240\u4ee5\u5177\u6709\u6f54\u6de8\u6027\uff0c\u6b64\u5916\u6d6e\u6e38\u751f\u7269\u7121\u6cd5\u9032\u884c\u5149\u5408\u4f5c\u7528\uff0c\u9020\u6210\u7121\u6a5f\u9e7d\u985e\u7121\u6cd5\u88ab\u6d6e\u6e38\u751f\u7269\u6d88\u8017\uff0c\u56e0\u800c\u7121\u6a5f\u9e7d\u985e\u5927\u91cf\u7d2f\u7a4d\u65bc DOW \u5167\uff0c\u56e0\u6b64 DOW \u5177\u6709\u5bcc\u542b\u71df\u990a\u9e7d\u4e4b\u7279\u6027 (Hwang, Kim et al. 2009)\u3002\u5728DOW \u5c0d\u65bc\u6539\u5584\u4ee3\u8b1d\u75c7\u5019\u7fa4\uff0c\u9810\u9632\u80a5\u80d6\u8207\u8abf\u7bc0\u8840\u8102\u4e4b\u7814\u7a76\u5df2\u9678\u7e8c\u88ab\u767c\u8868\u63d0\u51fa\u3002\u904e\u53bb\u7814\u7a76\u6307\u51faDOW \u986f\u8457\u6e1b\u5c11\u8840\u6e05\u4e2dtriglyceride (TG) \u542b\u91cf\uff0c\u6291\u5236\u526f\u776a\u5468\u570d\u8207\u8179\u8154\u5167\u8102\u80aa\u7d44\u7e54\u4e4b\u7d30\u80de\u5927\u5c0f\uff0c\u63d0\u9ad8\u8102\u80aa\u9178\u6c27\u5316\u76f8\u95dc\u86cb\u767d acetyl-CoA carboxylase (ACC) \u8868\u73fe\u91cf\uff0c\u6b64\u5916 DOW \u53ef\u63d0\u9ad8\u8102\u8cea\u5206\u89e3\u76f8\u95dc\u4e4b peroxisome proliferator-activated receptor-α (PPAR-α)\u3001cluster of differentiation 36 (CD36)\uff0c\u4ee5\u53ca\u80fd\u91cf\u6d88\u8017\u76f8\u95dc\u4e4b uncoupling protein 2 (UCP2)\u3001carnitine palmitoyltransferase-1 (CPT1)\uff0c\u6291\u5236\u8102\u8cea\u751f\u6210\u76f8\u95dc\u4e4b sterol regulatory element-binding protein-1 (SREBP1) \u7684 mRNA \u8868\u73fe\u91cf\uff0c\u56e0\u6b64\u53ef\u77e5 DOW \u5177\u6709\u6291\u5236\u8102\u8cea\u751f\u6210\u8207\u63d0\u9ad8\u8102\u8cea\u5206\u89e3\uff0c\u907f\u514d\u80a5\u80d6\u7522\u751f\u4e4b\u529f\u6548 (Yuan et al., 2015)\u30022013 \u5e74 Cheng \u7b49\u4eba\u5c0d DOW \u6291\u5236\u9ad8\u6cb9\u8102\u98f2\u98df\u5927\u9f20\u809d\u81df\u8102\u8cea\u5806\u7a4d\u8207\u6c27\u5316\u4e4b\u6548\u679c\u9032\u884c\u63a2\u8a0e\uff0c\u5be6\u9a57\u7d50\u679c\u8868\u793a DOW \u6709\u52a9\u65bc\u964d\u4f4e\u809d\u81df\u5167 malondialdehyde (MDA) \u542b\u91cf\uff0c\u6291\u5236\u809d\u7d30\u80de\u5167\u8102\u6ef4\u5f62\u6210\uff0c\u964d\u4f4e\u8840\u6e05\u4e2daspartate aminotransferase (AST) \u8207 alanine aminotransferase (ALT) \u6d3b\u6027\uff0c\u4ee5\u53ca\u589e\u52a0\u809d\u81df\u5167\u8102\u8cea\u53ca\u80fd\u91cf\u4ee3\u8b1d\u76f8\u95dc\u4e4bPPAR-α\u3001retinoid X receptor α (RXR-α) \u8207 UCP2 mRNA \u8868\u73fe\u91cf\uff0cDOW \u8868\u73fe\u51fa\u5177\u6709\u6539\u5584\u809d\u81df\u8102\u8cea\u5806\u7a4d\u53ca\u6c27\u5316\u4e4b\u6548\u679c (Chen, Chang et al. 2013)\u3002<\/p>\n
\u6839\u64da\u904e\u53bb\u7814\u7a76\u6307\u51fa\uff0cDOW\u5177\u6709\u9810\u9632\u4ee3\u8b1d\u75c7\u5019\u7fa4\u8207\u8abf\u7bc0\u8840\u8102\u4e4b\u529f\u80fd\uff0c\u4f46\u76ee\u524d\u7814\u7a76\u5c0d\u65bc\u4e0d\u540c\u7926\u7269\u8cea\u7d44\u6210\u4e4b\u6df1\u5c64\u6d77\u6c34\u5c0d\u65bc\u8102\u80aa\u809d\u6539\u5584\u4e4b\u7814\u7a76\u4ecd\u8f03\u5c11\u3002\u65bc\u81fa\u7063\u6df1\u5c64\u6d77\u6c34\u8cc7\u6e90\u5229\u7528\u5b78\u6703\u6240\u59d4\u8a17\u4e4b\u7814\u7a76\u4e2d\u9032\u884c\u6bd4\u8f03\u7d93\u7531\u4e0d\u540c\u5206\u6c34\u6280\u8853\u8655\u7406\u5f8c\u7684DOW\u5c0d\u65bc\u975e\u9152\u7cbe\u6027\u8102\u80aa\u4e4b\u6539\u5584\u6548\u679c\u3002\u4e0d\u540c\u5206\u6c34\u6280\u8853\u53ef\u7372\u5f97\u5404\u7a2e\u4e0d\u540c\u7926\u7269\u8cea\u7d44\u6210\u4e4b DOW\uff0c\u5176\u4e3b\u8981\u7531\u7d93\u6fdf\u90e8\u6771\u90e8\u6df1\u5c64\u6d77\u6c34\u5275\u65b0\u7814\u767c\u4e2d\u5fc3\u9032\u884c\u5206\u6c34\u8207\u63d0\u4f9b\uff0c\u662f\u4ee5\u53d6\u81ea\u81fa\u6771 DOW \u539f\u6c34\u9032\u884c\u4e0d\u540c\u5206\u6c34\u8655\u7406\u4e4b DOW\u3002\u5206\u5225\u70ba\u542b\u9ad8\u9382\u6bd4\u4f8b\u4e4b DOW\u3001\u542b\u9ad8\u9382\u9ad8\u9223\u6bd4\u4f8b\u4e4b DOW \u8207\u542b\u9ad8\u9382\u9ad8\u9223\u9ad8\u7926\u7269\u8cea\u6bd4\u4f8b\u4e4b DOW\u3002\u6b64\u7814\u7a76\u63a1\u7528\u8cfc\u81ea\u8ca1\u5718\u6cd5\u4eba\u570b\u5bb6\u5be6\u9a57\u52d5\u7269\u7814\u7a76\u9662\u5be6\u9a57\u52d5\u7269\u4e2d\u5fc3\u4e4b 6 \u5468\u9f61 C57BL\/6J \u54c1\u7cfb\u96c4\u6027\u5c0f\u9f20\uff0c\u81ea\u7531\u651d\u98df\u53ca\u98f2\u6c34\u4e26\u9810\u990a \u3109\u5468\u9069\u61c9\u74b0\u5883\u5f8c\u9032\u884c 15 \u9031\u5be6\u9a57\uff0c\u5be6\u9a57\u671f\u9593\u6b63\u5e38\u98f2\u98df\u52d5\u7269\u70ba\u81ea\u7531\u9032\u98df\u6b63\u5e38\u98fc\u6599 (\u8102\u80aa\u542b\u91cf 5~6%) \u7d44\u5176\u9918\u7d44\u5225\u9032\u98df\u9ad8\u6cb9\u8102\u98f2\u98df (\u8102\u80aa\u71b1\u91cf\u767e\u5206\u6bd4 45%) \u7d44\uff0c\u8a66\u9a57\u7d44\u4e26\u540c\u6642\u6bcf\u65e5\u7ba1\u9935\u9ad8\u9382\u6bd4\u4f8b\u4e4b DOW\u3001\u9ad8\u9382\u9ad8\u9223\u6bd4\u4f8b\u4e4b DOW \u6216\u9ad8\u9382\u9ad8\u7926\u7269\u8cea\u6bd4\u4f8b\u4e4b DOW\u3002\u8a66\u9a57\u9032\u884c 15 \u5468\uff0c\u52d5\u7269\u98f2\u7528\u5291\u91cf\u76f8\u7576\u65bc 60 \u516c\u65a4\u6210\u4eba\u6bcf\u4eba\u6bcf\u5929\u98f2\u7528 500 mL \u786c\u5ea6 1400 \u4e4b DOW\u3002\u6839\u64da\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5728\u5404\u9805\u6307\u6a19\u4e2d\u986f\u793a\uff0c\u9023\u7e8c 15 \u5468\u9935\u98df\u9ad8\u6cb9\u8102\u98f2\u98df\u7d44\u4e4b\u9ad4\u8102\u80aa\u91cf\u3001\u8840\u8102\u3001\u8840\u7cd6\u3001ALT\u3001AST \u8207\u809d\u81df\u4e09\u9178\u7518\u6cb9\u916f\u5747\u986f\u8457\u9ad8\u65bc\u6b63\u5e38\u98f2\u98df\u7d44\uff0c\u9020\u6210\u660e\u986f\u8102\u80aa\u809d\u4e4b\u75c5\u5fb5\u3002\u800c\u5728\u9935\u98df\u4e09\u7a2e\u4e0d\u540c\u7926\u7269\u8cea\u7d44\u6210\u4e4b DOW \u5f8c\u5747\u5728\u5404\u9805\u6307\u6a19\u4e2d\u5747\u5177\u6709\u4e0d\u540c\u7a0b\u5ea6\u964d\u4f4e\u9ad4\u8102\u80aa\u91cf\u4e4b\u6548\u679c\uff0c\u5176\u4e2d\u9ad8\u9382\u9ad8\u9223\u6bd4\u4f8b\u4e4b DOW \u5177\u6709\u6700\u4f73\u4e4b\u964d\u4f4e\u7e3d\u9ad4\u8102\u80aa\u91cf\u3001\u809d\u81df\u4e09\u9178\u7518\u6cb9\u916f\u8207\u8abf\u7bc0\u8840\u7cd6\u4e4b\u6548\u679c\u3002\u9ad8\u9382\u9ad8\u9223\u9ad8\u7926\u7269\u8cea\u6bd4\u4f8b\u4e4b DOW \u6700\u5177\u6709\u986f\u8457\u6539\u5584\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u800c\u964d\u4f4e AST \u8207ALT \u4e4b\u6548\u679c\uff0c\u9ad8\u9382\u6bd4\u4f8b\u4e4b DOW \u4e5f\u5177\u6709\u964d\u4f4e ALT \u8207 AST \u4e4b\u6548\u679c\uff0c\u4f46\u5c0d\u65bc\u7e3d\u81bd\u56fa\u9187\u4e4b\u8abf\u964d\u65b9\u9762\u5247\u5448\u73fe\u8f03\u7de9\u6162\u4e4b\u8da8\u52e2\u3002\u9019\u4e9b\u7d50\u679c\u7684\u4e0d\u540c\u9664\u4e86\u8207 Mg\u3001Ca \u6fc3\u5ea6\u7684\u5dee\u7570\u5916\uff0c\u4e5f\u53ef\u80fd\u662f DOW \u4e2d\u5176\u4ed6\u7926\u7269\u8cea\u7d44\u6210\u7684\u4e0d\u540c\u800c\u5f71\u97ff\u3002\u6b64\u7814\u7a76\u672a\u4f86\u6709\u52a9\u65bc\u9032\u4e00\u6b65\u4e86\u89e3 DOW \u7926\u7269\u8cea\u7d44\u6210\u5c0d\u65bc\u8102\u80aa\u809d\u9810\u9632\u4e4b\u6539\u5584\u4f5c\u7528\u6a5f\u8f49\u3002<\/p>\n
\u53c3\u8003\u6587\u737b<\/p>\n
Bedogni, G. and S. Bellentani (2004). "Fatty liver: how frequent is it and why?" Ann Hepatol 3(2): 63-65.<\/p>\n
Brunt, E. M. (2001). "Nonalcoholic steatohepatitis: definition and pathology." Semin Liver Dis 21(1): 3-16.<\/p>\n
Chen, I. S., Y. Y. Chang, C. L. Hsu, H. W. Lin, M. H. Chang, J. W. Chen, S. S. Chen and Y. C. Chen (2013). "Alleviative effects of deep-seawater drinking water on hepatic lipid accumulation and oxidation induced by a high-fat diet." J Chin Med Assoc 76(2): 95-101.<\/p>\n
Hwang, H. S., H. A. Kim, S. H. Lee and J. W. Yun (2009). "Anti-obesity and antidiabetic effects of deep sea water on ob\/ob mice." Mar Biotechnol (NY) 11(4): 531-539.<\/p>\n
McClain, C. J., S. P. Mokshagundam, S. S. Barve, Z. Song, D. B. Hill, T. Chen and I. Deaciuc (2004). "Mechanisms of non-alcoholic steatohepatitis." Alcohol 34(1): 67-79.<\/p>\n
Musso, G., R. Gambino, F. De Michieli, M. Cassader, M. Rizzetto, M. Durazzo, E. Faga, B. Silli and G. Pagano (2003). "Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis." Hepatology 37(4): 909-916.<\/p>\n
Sanyal, A. J., C. Campbell-Sargent, F. Mirshahi, W. B. Rizzo, M. J. Contos, R. K. Sterling, V. A. Luketic, M. L. Shiffman and J. N. Clore (2001). "Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities." Gastroenterology 120(5): 1183-1192.<\/p>\n
Westwater, J. O. and D. Fainer (1958). "Liver impairment in the obese." Gastroenterology 34(4): 686-693.<\/p>\n","protected":false},"excerpt":{"rendered":"
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