\u96a8\u8457\u793e\u6703\u7d93\u6fdf\u7684\u7e41\u69ae\u53ca\u751f\u6d3b\u578b\u614b\u548c\u98f2\u98df\u65b9\u5f0f\u6539\u8b8a\uff0c\u570b\u5167\u7cd6\u5c3f\u75c5\u60a3\u4eba\u53e3\u6578\u5df2\u9054\u767e\u842c\u3002\u5176\u4e2d\u4e5d\u6210\u4ee5\u4e0a\u5c6c\u65bc\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u3002\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u7684\u4e3b\u8981\u81f4\u75c5\u539f\u56e0\u70ba\u8eab\u9ad4\u7522\u751f\u300c\u80f0\u5cf6\u7d20\u963b\u6297\u300d\u7684\u73fe\u8c61\u3002\u96d6\u7136\u80f0\u81df\u5206\u6ccc\u80f0\u5cf6\u7d20\uff0c\u4f46\u56e0\u70ba\u80a5\u80d6\u5c0e\u81f4\u5168\u8eab\u7d30\u80de\u5c0d\u65bc\u80f0\u5cf6\u7d20\u7684\u654f\u611f\u6027\u964d\u4f4e\uff0c\u4f7f\u5f97\u8840\u6db2\u4e2d\u7684\u8461\u8404\u7cd6\u7121\u6cd5\u9032\u5165\u7d30\u80de\u4e2d\u88ab\u5229\u7528\uff0c\u5c0e\u81f4\u8840\u6db2\u4e2d\u8840\u7cd6\u503c\u5347\u9ad8\u3002<\/p>\n
2013\u5e74\uff0cHa\u7b49\u4eba\u8abf\u914d\u786c\u5ea6\u5f9e500~2000\u7684\u6df1\u5c64\u6d77\u6c34\uff0c\u4ee5\u4e0d\u540c\u786c\u5ea6\u6df1\u5c64\u6d77\u6c34\u4f5c\u70ba\u98f2\u7528\u6c34(4 ml \u00b1 0.1\/day)\u642d\u914d\u9ad8\u8102\u98f2\u98df\u7684\u8001\u9f20\u7576\u4f5c\u5be6\u9a57\u7d44\uff0c\u800c\u81ea\u4f86\u6c34(4 ml \u00b1 0.1\/day)\u7576\u98f2\u7528\u6c34\u914d\u5408\u9935\u98df\u9ad8\u8102\u98f2\u98df\u7684\u8001\u9f20\u7576\u4f5c\u63a7\u5236\u7d44\u3002\u6bd4\u8f03\u5be6\u9a57\u7d44\u8207\u63a7\u5236\u7d44\u7d50\u679c\u5f8c\uff0c\u767c\u73fe\u5be6\u9a57\u7d44\u5728\u7a7a\u8179\u6642\u7684\u8840\u7cd6\u503c\u6bd4\u63a7\u5236\u7d44\u4f4e\u3002\u540c\u6642\u5728\u53e3\u670d\u8207\u8179\u819c\u5167(intraperitoneal) \u8461\u8404\u7cd6\u8010\u91cf\u8a66\u9a57\u4e2d\u767c\u73fe\uff0c\u6df1\u5c64\u6d77\u6c34\u53ef\u4ee5\u6539\u5584\u5be6\u9a57\u7d44\u7684\u8461\u8404\u7cd6\u4e0d\u8010\u53d7\u6027\u3002\u4e26\u7531\u8840\u7cd6\u9f20\u9023\u7e8c\u98f2\u7528\u786c\u5ea62000\u7684\u6df1\u5c64\u6d77\u6c3420\u5468\u5f8c\uff0c\u5728\u9ad4\u91cd\u4e0a\u96d6\u7136\u6c92\u6709\u660e\u986f\u8b8a\u5316\u3002\u4f46\u8840\u6db2\u8207\u809d\u81df\u4e2d\u4e09\u9178\u7518\u6cb9\u8102\u6709\u660e\u986f\u6e1b\u5c11\u73fe\u8c61(81.2 \u00b1 6.4 – > 49.6 \u00b1 7.5\uff1b246.5 \u00b1 19.9- > 187.5 \u00b1 7.6)\uff0c\u540c\u6642\u80f0\u5cf6\u7d20\u542b\u91cf\u4e5f\u6709\u660e\u986f\u589e\u52a0\u8da8\u52e2(3.6 \u00b1 0.1- > 6.3 \u00b1 0.8)\u3002\u8b49\u5be6\u786c\u5ea6\u5169\u5343\u7684\u6df1\u5c64\u6d77\u6c34\u53ef\u6539\u5584\u80a5\u80d6\u9020\u6210\u7684\u80f0\u5cf6\u7d20\u5206\u6ccc\u904e\u5c11\u73fe\u8c61\uff0c\u540c\u6642\u6e1b\u5c11\u8840\u6db2\u8207\u809d\u81df\u7684\u4e09\u9178\u7518\u6cb9\u8102\u542b\u91cf\u3002<\/p>\n
\u8a31\u591a\u7814\u7a76\u8b49\u5be6\u80a5\u80d6\u8005\u9ad4\u5167\u8207\u80f0\u5cf6\u7d20\u8abf\u63a7\u6709\u76f8\u95dc\u6027\u7684\u8cc0\u723e\u8499\u6703\u6e1b\u5c11\uff0c\u4f8b\u5982\u8102\u806f\u7d20(adiponectin) \u548c\u7626\u9ad4\u7d20 (leptin)\u3002\u7814\u7a76\u6307\u51fa\u8102\u806f\u7d20\u542b\u91cf\u6e1b\u5c11\u6703\u5c0e\u81f4\u80a5\u80d6\uff0c\u800c\u7626\u9ad4\u7d20\u5247\u6703\u5c0e\u81f4\u7cd6\u5c3f\u75c5\u3002\u6839\u64da\u5be6\u9a57\u4e2d\u767c\u73fe\uff0c\u4f34\u96a8\u8457\u98f2\u7528\u786c\u5ea62000\u7684\u6df1\u5c64\u6d77\u6c34\u4f7f\u5f97\u80f0\u5cf6\u7d20\u8207\u8102\u806f\u7d20\u542b\u91cf\u589e\u52a0\uff0c\u540c\u6642\u6e1b\u5c11\u767c\u708e\u7d30\u80de\u56e0\u5b50: \u767d\u7d30\u80de\u4ecb\u7d20 [interleukin-6 (IL-6)] \u548c \u816b\u7624\u58de\u6b7b\u56e0\u5b50 [tumor necrosis factor-α (TNF-α)]\uff0c\u4e26\u4e14\u63d0\u5347\u7d30\u80de\u5c0d\u80f0\u5cf6\u7d20\u654f\u611f\u5ea6\uff0c\u4f7f\u8840\u6db2\u4e2d\u8461\u8404\u7cd6\u80fd\u9032\u5165\u7d30\u80de\u5167\u9032\u884c\u4ee3\u8b1d\u53cd\u61c9\u30022013\u5e74\uff0cRaucci\u7b49\u4eba\u7814\u7a76\u6307\u51fa\u8102\u80aa\u7d30\u80de\u4e2d\u7684\u767c\u708e\u53cd\u61c9\u6703\u9020\u6210\u80f0\u5cf6\u7d20\u963b\u6297\u73fe\u8c61\u7522\u751f\uff0cBastard \u7b49\u4eba\u4e5f\u5728\u80a5\u80d6\u7684\u56d3\u9f52\u52d5\u7269\u8207\u4eba\u9ad4\u4e2d\u767c\u73fe\uff0c\u767c\u708e\u57fa\u56e0\u8868\u73fe\u6703\u9020\u6210\u80f0\u5cf6\u7d20\u62ee\u6297\u73fe\u8c61\u7522\u751f\u3002\u800c\u98f2\u7528\u6df1\u5c64\u6d77\u6c34\u53ef\u6291\u5236\u767c\u708e\u56e0\u5b50\u7522\u751f\u4e26\u4e14\u589e\u52a0\u80f0\u5cf6\u7d20\u5206\u6ccc\u91cf\u540c\u6642\u6539\u5584\u80f0\u5cf6\u7d20\u62ee\u6297\u4f5c\u7528\u3002<\/p>\n
\u800c\u7f3a\u4e4f\u80f0\u5cf6\u7d20\u4f5c\u7528\u7684\u52d5\u7269\u9ad4\u5167\u7684\u7cd6\u8cea\u65b0\u751f(gluconeogenesis)\u3001\u809d\u91a3\u5408\u6210(Glycogenesis)\u3001\u809d\u91a3\u5206\u89e3(Glycogenolysis)\u4e09\u7a2e\u6a5f\u5236\u7686\u53d7\u5f71\u97ff\u3002\u7cd6\u8cea\u65b0\u751f: \u80f0\u5cf6\u7d20\u56de\u994b\u6291\u5236(feedback control) \u6607\u7cd6\u7d20((glucagon)\uff0c\u7531\u65bc\u7cd6\u5c3f\u75c5\u7684\u80f0\u5cf6\u7d20\u70ba\u5206\u6ccc\u4e0d\u8db3\u6216\u6709\u7f3a\u9677\uff0c\u9020\u6210\u7cd6\u8cea\u65b0\u751f\u6548\u7387\u589e\u52a0\u3001\u809d\u7cd6\u5408\u6210\u6548\u7387\u6e1b\u5c11\u4ee5\u53ca\u809d\u7cd6\u5206\u89e3\u6548\u7387\u63d0\u5347\u3002\u7d93\u98f2\u7528\u6df1\u5c64\u6d77\u6c34\u6578\u64da\u8b49\u5be6\u6703\u6e1b\u5c11\u7cd6\u8cea\u65b0\u751f\u9175\u7d20phosphoenolpyruvate carboxykinase (PEPCK) \u3001glucose 6-phosphatase (G6Pase) \u53ca\u809d\u7cd6\u78f7\u89e3\u9176(liver glycogen phosphorylase)\u7684\u6d3b\u6027\u3002\u6b64\u5916\u63d0\u5347\u809d\u7cd6\u5408\u6210\u9176 (glycogen synthase) \u6d3b\u6027\u4fc3\u4f7f\u8461\u8404\u7cd6\u8f49\u8b8a\u809d\u7cd6\u5132\u5b58\u3002\u4e26\u4e14\u63d0\u5347Glut 4\u86cb\u767d\u8868\u73fe\u91cf\uff0c\u85c9\u6b64\u904b\u9001\u8840\u6db2\u4e2d\u8461\u8404\u7cd6\u5230\u8102\u80aa\u53ca\u808c\u8089\u7d44\u7e54\u5167\u4ee5\u4f9b\u5229\u7528\u3002<\/p>\n
\u7d50\u5408\u4ee5\u4e0a\u8ad6\u9ede\uff0c\u98f2\u7528\u786c\u5ea6\u5169\u5343\u7684\u6df1\u5c64\u6d77\u6c34\u5728\u9ad8\u8102\u98f2\u98df\u8a98\u767c\u7684\u7cd6\u5c3f\u75c5\u9f20\u4e2d\uff0c\u589e\u52a0\u80f0\u5cf6\u7d20\u8868\u73fe\u91cf\u3001\u6291\u5236\u7cd6\u8cea\u65b0\u751f\u53ca\u809d\u7cd6\u5206\u89e3\u6548\u7387\u53ca\u63d0\u5347\u809d\u7cd6\u5408\u6210\u6548\u7387\uff0c\u4e26\u63d0\u5347\u8461\u8404\u7cd6\u904b\u9001\u86cb\u767d\u91cf\u4f86\u964d\u4f4e\u7cd6\u5c3f\u75c5\u9f20\u8840\u6db2\u4e2d\u7684\u8461\u8404\u7cd6\u542b\u91cf\u3002\u6545\u6df1\u5c64\u6d77\u6c34\u6709\u975e\u5e38\u5927\u6a5f\u6703\u505a\u70ba\u4e00\u500b\u8abf\u63a7\u80a5\u80d6\u3001\u8840\u7cd6\u7684\u6f5b\u529b\u539f\u6599\u3002<\/p>\n
\u53c3\u8003\u6587\u737b:
\n Ha BG, Shin EJ, Park JE, Shon YH. Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice. Mar Drugs. 2013, 11, 4193-212.
\n Raucci R., Rusolo F., Sharma, A., Colonna, G., Castello, G. and Costantini S. Functional and structural features of adipokine family. Cytokine 2013, 61, 1\u201314.
\n Bastard, J.P. Maachi, M. Lagathu, C. Kim, M.J. Caron, M. Vidal, H. Capeau, J. Feve, B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 2006, 17, 4\u201312.<\/p>\n","protected":false},"excerpt":{"rendered":"
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[…]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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