1\u3001\u51ac\u87f2\u590f\u8349\u8207\u86f9\u87f2\u8349\u4e4b\u751f\u7269\u5b78\u7279\u6027<\/p>\n
\u51ac\u87f2\u590f\u8349\u53c8\u540d\u590f\u8349\u51ac\u87f2\u3001\u87f2\u8349\u3001\u51ac\u87f2\u8349\uff0c\u662f\u4e00\u7a2e\u83cc\u87f2\u8907\u5408\u9ad4\uff0c\u50b3\u7d71\u4e0a\u6240\u7a31\u7684\u51ac\u87f2\u590f\u8349\u5b78\u540d\u70ba Cordyceps sinensis (Berk.) Sacc.\uff0c\u610f\u6307\u70ba\u5728\u4e2d\u570b\u5730\u5340\u767c\u73fe\u7684\u87f2\u8349\u5c6c\u771f\u83cc\u54c1\u7a2e\uff0c\u76f4\u8b6f\u70ba\u4e2d\u83ef\u87f2\u8349\u6216\u4e2d\u570b\u87f2\u8349\uff0c\u70ba\u9ea5\u89d2\u83cc\u79d1\u771f\u83cc\uff0c\u53ef\u5bc4\u5bbf\u5728\u9c57\u7fc5\u76ee\u3001\u9798\u7fc5\u76ee\u7b49\u6606\u87f2\u7684\u5e7c\u87f2\uff0c\u5176\u4e2d\u4ee5\u5bc4\u751f\u5728\u8759\u8760\u86fe\u79d1\u6606\u87f2\u8759\u8760\u86fe(Hepialus armoricanus Oberthur.)\u7684\u5e7c\u87f2\u70ba\u6b63\u5b97(\u884c\u653f\u9662\u885b\u751f\u7f72\u4e2d\u91ab\u85e5\u59d4\u54e1\u6703\uff0c1985)\u3002\u51ac\u87f2\u590f\u8349\u6309\u5bc4\u751f\u5bbf\u4e3b\u7684\u4e0d\u540c\u5206\u70ba\u8a31\u591a\u4e9e\u7a2e\uff0c\u5176\u4e2d\u86f9\u87f2\u8349(Cordyceps militaris LS901) \u4e8e1951 \u5e74\u88ab\u6aa2\u6e2c\u51fa\u542b\u6709\u87f2\u8349\u7d20(Cordycepin)\u5f8c\u53d7\u5230\u6ce8\u76ee(Cunningham et al., 1950)\u3002\u86f9\u87f2\u8349\u4e3b\u8981\u7522\u65bc\u4e2d\u570b\u6771\u5317\u90e8\uff0c\u53c8\u7a31\u70ba\u5317\u51ac\u87f2\u590f\u8349\uff0c\u662f\u7531\u86f9\u87f2\u8349\u83cc (C. militaris)\u5bc4\u751f\u5728\u6606\u87f2\u4e4b\u86f9\u767c\u80b2\u800c\u6210\uff0c\u53ef\u611f\u67d3\u8f03\u5ee3\u6cdb\u4e4b\u5bc4\u4e3b\uff0c\u5176\u4e2d\u4e3b\u8981\u70ba\u9c57\u7fc5\u76ee\u7684\u821f\u86fe\u79d1\u3001\u5929\u86fe\u79d1\u3001\u5927\u8836\u86fe\u79d1\u3001\u8836\u86fe\u79d1\u8207\u523a\u86fe\u79d1\u7b49(\u838a\u7b49\uff0c2003)\uff0c\u6709\u7814\u7a76\u6307\u51fa\u5176\u6d3b\u6027\u6210\u5206\u8207\u51ac\u87f2\u590f\u8349\u76f8\u4f3c(Ikumoto et al., 1991)\uff0c\u50b3\u7d71\u4e0a\u53ef\u4f5c\u70ba\u51ac\u87f2\u590f\u8349\u7684\u66ff\u7528\u54c1\u3002<\/p>\n
2\u3001\u51ac\u87f2\u590f\u8349\u65bc\u50b3\u7d71\u4e0a\u4e4b\u904b\u7528\u8207\u6b77\u53f2
\n \u51ac\u87f2\u590f\u8349\u5728\u50b3\u7d71\u4e2d\u85e5\u4e2d\u70ba\u7a00\u6709\u73cd\u8cb4\u7684\u4e2d\u85e5\u6750\uff0c\u95dc\u65bc\u51ac\u87f2\u590f\u8349\u6700\u65e9\u7684\u6b63\u5f0f\u5165\u85e5\u6587\u737b\uff0c\u662f\u6e05\u671d\u6c6a\u6602\u6240\u8457\u7684\u300a\u672c\u8349\u5099\u8981\u300b(1694)\uff0c\u66f8\u4e2d\u8a18\u8f09\uff1a\u300c\u51ac\u87f2\u590f\u8349\uff0c\u7518\u5e73\uff0c\u4fdd\u80ba\u76ca\u814e\uff0c\u6b62\u8840\u5316\u75f0\uff0c\u6b62\u52de\u54b3\u3002\u56db\u5ddd\u5609\u5b9a\u5e9c\u6240\u7522\u8005\u70ba\u4f73\u3002\u51ac\u5728\u571f\u4e2d\uff0c\u5f62\u5982\u8001\u8836\uff0c\u6709\u6bdb\u80fd\u52d5\uff0c\u81f3\u590f\u5247\u6bdb\u51fa\u571f\u4e0a\uff0c\u9023\u8eab\u4ff1\u5316\u70ba\u8349\u3002\u82e5\u4e0d\u53d6\uff0c\u81f3\u51ac\u8907\u5316\u70ba\u87f2\u3002\u300d\uff0c\u8d99\u5b78\u654f\u5247\u5728\u300a\u672c\u8349\u7db1\u76ee\u62fe\u907a\u300b\uff081756\uff09\u4e2d\u5beb\u9053\uff1a\u300c\u51ac\u87f2\u590f\u8349\uff0c\u4e00\u7269\u4e5f\uff0c\u51ac\u5247\u70ba\u87f2\uff0c\u590f\u5247\u70ba\u8349…\uff0c\u529f\u7528\u8207\u4eba\u53c3\u540c\uff0c\u80fd\u81f3\u8af8\u865b\u767e\u640d\u300d\uff0c\u5433\u5100\u6d1b\u5728\u300a\u672c\u8349\u5f9e\u65b0\u300b(1757)\u4e2d\u5beb\u9053\uff1a\u300c\u51ac\u87f2\u590f\u8349\u4fdd\u80ba\u76ca\u814e\u3001\u6b62\u8840\u5316\u75f0\u3002\u300d\u81f3\u4eca\u5df2\u6709\u767e\u90e8\u4e2d\u85e5\u6587\u737b\u5c0d\u51ac\u87f2\u590f\u8349\u7684\u529f\u6548\u9032\u884c\u7684\u8a18\u8f09\u3002<\/p>\n
3\u3001\u87f2\u8349\u7684\u751f\u7406\u6d3b\u6027<\/p>\n
3-1\u3001\u8abf\u7bc0\u514d\u75ab\u7cfb\u7d71<\/p>\n
\u51ac\u87f2\u590f\u8349\u8403\u53d6\u7269\u5373\u5176\u4e2d\u4e4b\u6c34\u8403\u7269\u8207\u591a\u91a3\u9ad4\u53ef\u5c0d\u9ad4\u6db2\u514d\u75ab\u8207\u7d30\u80de\u514d\u75ab\u9032\u884c\u96d9\u5411\u7684\u8abf\u7bc0\uff0c\u5305\u62ec\u589e\u52a0\u6a39\u7a81\u7d30\u80de\u8207\u8f14\u52a9\u578bT \u7d30\u80de(helper T cell)\u7684\u6d3b\u6027\uff0c\u63d0\u5347\u81ea\u7136\u6bba\u624b\u7d30\u80de(NK cell)\u7684\u541e\u566c\u80fd\u529b\uff0c\u8abf\u7bc0\u5982IL-2\u3001IL-12 \u7b49\u591a\u7a2e\u7d30\u80de\u6fc0\u7d20\u4ee5\u53ca\u6297\u9ad4\u7684\u5206\u6ccc(Chen et al., 1991; Wu et al., 2006)\uff0c\u4e14\u51ac\u87f2\u590f\u8349\u53ef\u6e1b\u7de9\u5316\u7642\u85e5\u7269\u6291\u6b62\u9aa8\u9ad3\u751f\u9577\u6240\u5f15\u767c\u7684\u767d\u8840\u7403\u4f4e\u4e0b\u73fe\u8c61\uff0c\u4e26\u4fc3\u9032\u53d7\u8f3b\u5c04\u7167\u5c04\u5f8c\u5c0f\u9f20\u9aa8\u9ad3\u7d30\u80de\u7684\u589e\u751f(Liu et al., 2008; Liu et al., 2006)\u3002\u86f9\u87f2\u8349\u7684\u6c34\u8403\u7269\u53ef\u4fc3\u4f7f\u6a39\u7a81\u7d30\u80de\u5728\u7d44\u7e54\u8207\u6a5f\u80fd\u6027\u7684\u6210\u719f\uff0c\u9032\u800c\u63d0\u5347\u6bba\u624b\u578bT \u7d30\u80de(cytotoxic T cell)\u7684\u6d3b\u6027(Kim et al., 2006a)<\/p>\n
3-2\u3001\u6291\u5236\u816b\u7624\u751f\u9577<\/p>\n
\u51ac\u87f2\u590f\u8349\u7684\u83cc\u7d72\u9ad4\u9187\u7cb9\u53d6\u7269\u80fd\u6291\u5236HL-60\u3001MCF-7\u3001B16\u3001HepG2 \u7b49\u7d30\u80de\u682a\u7684\u751f\u9577\uff0c\u4e14\u80fd\u6e1b\u7de9\u5c0f\u9f20\u9ad4\u5167\u9ed1\u8272\u7d20\u7624(melanoma)B16 \u7684\u751f\u9577\u901f\u5ea6(Wu et al., 2007)\uff0c\u51ac\u87f2\u590f\u8349\u7684\u6c34\u8403\u7269\u5247\u53ef\u4ee5\u6291\u5236Lewis lung carcinoma (LLC)\u4ee5\u53ca\u9ed1\u8272\u7d20\u7624B16 \u7684\u8f49\u79fb\u60c5\u5f62(Nakamura et al., 1999)\u3002\u86f9\u87f2\u8349\u7684\u6c34\u8403\u7269\u5247\u662f\u80fd\u900f\u904e\u6291\u5236\u80ba\u764c\u7d30\u80deA549 \u7d30\u80de\u682a\u4e2d\u7aef\u7c92\u9176\u7684\u6d3b\u6027\u9032\u800c\u6291\u5236\u5176\u751f\u9577(Park et al., 2009)\uff0c\u4e14\u80fd\u589e\u52a0\u4e73\u764c\u7d30\u80deMDA-MB-231 \u4e2dcaspases \u7684\u6d3b\u6027\u9032\u800c\u4fc3\u9032\u5176\u6b7b\u4ea1(Jin et al., 2008)\u3002<\/p>\n
3-3\u3001\u6539\u5584\u547c\u5438\u7cfb\u7d71<\/p>\n
\u51ac\u87f2\u590f\u8349\u7684\u6709\u6a5f\u8403\u53d6\u7269\u80fd\u6291\u5236\u652f\u6c23\u7ba1\u80ba\u6ce1\u704c\u6d17\u51fa\u7684\u7d30\u80de(bronchoalveolar lavage fluids cell)\u7522\u751f\u767c\u708e\u53cd\u61c9(Kuo et al., 2001)\u3002\u51ac\u87f2\u590f\u8349\u8207\u86f9\u87f2\u8349\u7684\u71b1\u6c34\u8403\u53d6\u7269\u7686\u53ef\u8abf\u63a7\u547c\u5438\u9053\u8868\u76ae\u7d30\u80de\u7684\u96e2\u5b50\u901a\u900f\u6027\uff0c\u4fc3\u9032\u5176\u5206\u6ccc\u9ecf\u6db2\uff0c\u9032\u800c\u9054\u5230\u4fdd\u8b77\u4e4b\u529f\u6548(Yue et al., 2008)\u3002<\/p>\n
3-4\u3001\u814e\u529f\u80fd<\/p>\n
\u51ac\u87f2\u590f\u8349\u7684\u8403\u53d6\u7269\u80fd\u4ee5\u5176\u6297\u6c27\u5316\u529b\u589e\u52a0\u814e\u81df\u7d30\u80de\u5c0d\u6bd2\u6027\u7269\u8cea\u6297\u6027(Wojcikowski et al., 2004)\uff0c\u6e1b\u7de9\u9ad8\u8840\u58d3\u60a3\u8005\u56e0angiotensin II \u904e\u91cf\u5c0e\u81f4\u7684\u814e\u5c0f\u7ba1\u8868\u76ae\u7d30\u80de\u6b7b\u4ea1\uff0c\u9032\u800c\u4fdd\u8b77\u814e\u81df(Tang et al., 2009)\u3002<\/p>\n
3-5\u3001\u5fc3\u8840\u7ba1\u7cfb\u7d71<\/p>\n
\u51ac\u87f2\u590f\u8349\u83cc\u7d72\u9ad4\u6c34\u8403\u7269\u80fd\u6709\u6548\u964d\u4f4e\u9ad8\u81bd\u56fa\u9187\u98f2\u98df\u6240\u5f15\u8d77\u7684\u9ad8\u8840\u8102\u75c7(Koh et al., 2003)\uff0c\u9187\u7cb9\u53d6\u7269\u5247\u53ef\u4ee5\u6291\u5236\u70cf\u982d\u9e7c\u5f15\u8d77\u7684\u5fc3\u5f8b\u4e0d\u6574(Mei et al., 1989)\u3002<\/p>\n
3-6\u3001\u809d\u529f\u80fd<\/p>\n
\u51ac\u87f2\u590f\u8349\u83cc\u7d72\u9ad4\u8403\u53d6\u7269\u53ef\u964d\u4f4e\u4e8c\u7532\u57fa\u4e9e\u785d\u80fa\u6240\u5f15\u8d77\u7684\u809d\u9580\u975c\u8108\u786c\u5316\u4ee5\u53ca\u809d\u7e96\u7dad\u5316(Li et al., 2006; Wang et al., 2008) \uff0c\u6db2\u614b\u57f9\u990a\u7684\u86f9\u87f2\u8349\u7684\u7d30\u80de\u5916\u751f\u7269\u9ad8\u805a\u7269(extracellular biopolymer)\u80fd\u6291\u5236\u5927\u9f20\u81bd\u7ba1\u5835\u585e\u5f8c\u5f15\u8d77\u7684\u809d\u7e96\u7dad\u5316\u73fe\u8c61(Nan et al., 2001)\u3002<\/p>\n
3-7\u3001\u6297\u8001\u5316<\/p>\n
\u51ac\u87f2\u590f\u8349\u8403\u53d6\u7269\u53ef\u589e\u52a0D-galactose \u8a98\u4f7f\u8001\u5316\u7684\u5c0f\u9f20\u7684\u8a18\u61b6\u529b\u8207\u5b78\u7fd2\u80fd\u529b\uff0c\u4e26\u589e\u52a0\u5176\u7d05\u8840\u7403\u3001\u8166\u8207\u809d\u4e2d\u8d85\u6c27\u5c90\u5316\u9176\u7684\u6297\u6c27\u5316\u80fd\u529b\uff0c\u6b64\u73fe\u8c61\u53ef\u80fd\u662f\u51ac\u87f2\u590f\u8349\u8403\u53d6\u7269\u4e2d\u6297\u6c27\u5316\u80fd\u529b\u8207\u53bb\u9664\u81ea\u7531\u57fa\u4e4b\u80fd\u529b\u6240\u5c0e\u81f4(Wang et al., 2004)\u3002<\/p>\n
3-8\u3001\u6027\u6a5f\u80fd<\/p>\n
\u4ee5\u51ac\u87f2\u590f\u8349\u8403\u53d6\u7269\u9935\u98df\u53bb\u52e2\u5927\u9f20\uff0c\u53ef\u4f7f\u5176\u52c3\u8d77\u6642\u9593\u5ef6\u9577(Ji et al., 2009)\uff0c\u800c\u86f9\u87f2\u8349\u53ef\u4ee5\u589e\u52a0\u5927\u9f20\u5177\u6709\u6d3b\u6027\u7684\u7cbe\u5b50\u7522\u91cf\u8207\u8840\u6e05\u4e2d\u776a\u4e38\u7d20\u6fc3\u5ea6(Chang et al., 2008)\u3002<\/p>\n
4\u3001\u6df1\u5c64\u6d77\u6c34\u61c9\u7528\u5728\u4eba\u5de5\u683d\u690d\u87f2\u8349
\n \u57281932\u5e74\u7531\u65e5\u672c\u7814\u7a76\u4eba\u54e1\u5c0f\u6797\u548c\u4e45\u5c71\u9996\u6b21\u4ee5\u7c73\u98ef\u57f9\u990a\u57fa\u4eba\u5de5\u683d\u57f9\u6210\u529f\uff0c\u76ee\u524d\u4eba\u5de5\u683d\u690d\u87f2\u8349\u591a\u662f\u4ee5\u767d\u7c73\u505a\u70ba\u57fa\u790e\u57f9\u990a\u57fa\u3002\u57f9\u990a\u65b9\u5f0f\u5206\u70ba\u6db2\u614b\u8207\u56fa\u614b\u57f9\u990a\uff0c\u9664\u4e86\u4ee5\u767d\u7c73\u70ba\u4e3b\u5916\uff0c\u53e6\u5916\u5c1a\u9700\u8981\u6dfb\u52a0\u6c2e\u6e90\u3001\u7121\u6a5f\u9e7d\u985e\u3001\u5fae\u91cf\u5143\u7d20\u7b49\u3002\u6df1\u5c64\u6d77\u6c34\u56e0\u70ba\u5177\u6709\u7926\u7269\u8cea\u5747\u8861\u3001\u5bcc\u71df\u990a\u9e7d\u7684\u7279\u6027\uff0c\u5728\u7c73\u57fa\u57f9\u990a\u57fa\u6210\u5206\u4efd\u4e2d\uff0c\u6dfb\u52a0\u6df1\u5c64\u6d77\u6c34\u7926\u7269\u9e7d\uff0c\u53ef\u4ee5\u63d0\u9ad8\u4eba\u5de5\u683d\u690d\u87f2\u8349\u7684\u83cc\u9ad4\u91cd\u91cf\uff0c\u53ca\u63d0\u9ad8\u87f2\u8349\u4e2d\u817a\u82f7\u3001\u87f2\u8349\u7d20\u3001\u7e3d\u591a\u915a\u53ca1,3-β-D-glucan\u7684\u542b\u91cf\uff0c\u53ef\u4ee5\u63d0\u9ad8\u6297\u75b2\u52de\u60c5\u5f62\u4e26\u5c0d\u8010\u4e45\u6027\u4e4b\u904b\u52d5\u5177\u6709\u6539\u5584\u751f\u7406\u529f\u80fd\u4e4b\u4f5c\u7528\u3002\u3002<\/p>\n
5\u3001\u4eba\u5de5\u683d\u690d\u87f2\u8349(\u6df1\u5c64\u6d77\u6c34\u61c9\u7528)\u8207\u91ce\u751f\u51ac\u87f2\u590f\u8349\u4e4b\u6bd4\u8f03<\/p>\n
\u51ac\u87f2\u590f\u8349\u662f\u4e00\u7a2e\u55dc\u4f4e\u6eab\u83cc\uff0c\u591a\u751f\u9577\u5728\u6d77\u62d43000~5000m \u7684\u9ad8\u5c71\u5340\uff0c\u4e3b\u8981\u7522\u5340\u5728\u897f\u85cf\u3001\u56db\u5ddd\u3001\u9752\u6d77\u3001\u96f2\u5357\u3001\u7518\u8085\u4e00\u4ee3\uff0c\u6703\u5728\u79cb\u5b63\u6642\u5165\u4fb5\u947d\u5165\u5730\u4e0b\u51ac\u7720\u7684\u8759\u8760\u86fe\u5e7c\u87f2\u9ad4\u5167\uff0c\u4ee5\u87f2\u9ad4\u70ba\u990a\u5206\u4e0d\u65b7\u7e41\u6b96\uff0c\u6700\u7d42\u5e7c\u87f2\u6703\u56e0\u9ad4\u5167\u5145\u6eff\u83cc\u7d72\u800c\u6b7b\u4ea1\u3002\u7576\u5929\u6c23\u8f49\u6696\u6642\u83cc\u7d72\u5f62\u6210\u7684\u5b50\u5ea7\u5f9e\u87f2\u9ad4\u982d\u90e8\u7834\u571f\u800c\u51fa\uff0c\u6210\u9802\u90e8\u5f6d\u5927\u7684\u68d2\u7403\u72c0\uff0c\u5e38\u88ab\u8aa4\u8a8d\u70ba\u8349(\u884c\u653f\u9662\u885b\u751f\u7f72\u4e2d\u91ab\u85e5\u59d4\u54e1\u6703\uff0c1985)\u3002\u51ac\u87f2\u590f\u8349\u662f\u4e00\u7a2e\u5b63\u7bc0\u6027\u975e\u5e38\u5f37\u7684\u85e5\u6750\uff0c\u82e5\u932f\u904e\u63a1\u6536\u6642\u7bc0\uff0c\u51ac\u87f2\u590f\u8349\u4fbf\u6703\u67af\u6b7b\uff0c\u85e5\u7528\u50f9\u503c\u5927\u5e45\u964d\u4f4e\u3002\u7531\u65bc\u5206\u5e03\u5340\u57df\u3001\u63a1\u6536\u5b63\u7bc0\u8207\u5bbf\u4e3b\u54c1\u7cfb\u7684\u9650\u5236\uff0c\u91ce\u751f\u87f2\u8349\u7684\u6578\u91cf\u7a00\u5c11\uff0c\u8fd1\u5e74\u4f86\u9010\u6f38\u958b\u767c\u51fa\u4ee5\u4eba\u5de5\u57f9\u690d\u7684\u6280\u8853\uff0c\u5305\u62ec\u611f\u67d3\u4eba\u5de5\u990a\u80b2\u7684\u5bb6\u8836\u3001\u6db2\u614b\u767c\u9175\u57f9\u990a\u6216\u56fa\u614b\u57f9\u990a\u57fa\u57f9\u990a\u7b49\u3002\u4eba\u5de5\u57f9\u690d\u7684\u87f2\u8349\u56e0\u751f\u9577\u74b0\u5883\u8f03\u7a69\u5b9a\uff0c\u5927\u591a\u542b\u6709\u8f03\u591a\u7684\u6a5f\u80fd\u6027\u6210\u5206\uff0c\u53ef\u7d93\u7531\u6eab\u5ea6\u7684\u8abf\u63a7\u53ef\u4f7f\u751f\u9577\u9031\u671f\u7e2e\u77ed\u3001\u63d0\u9ad8\u7522\u91cf\uff0c\u4e14\u4e0d\u6703\u6709\u5bbf\u4e3b\u6606\u87f2\u54c1\u7cfb\u4e0d\u660e\u6216\u91cd\u91d1\u5c6c\u7684\u5371\u5bb3(\u6842\u8207\u6731\uff0c2008)\u3002<\/p>\n
\u6c27\u6c23\u5728\u4ee3\u8b1d\u6642\u6703\u5f62\u6210\u5177\u6709\u9ad8\u5316\u5b78\u53cd\u61c9\u6027\u4e4b\u6d3b\u6027\u6c27\u6216\u81ea\u7531\u57fa\uff0c\u904e\u591a\u7684\u6d3b\u6027\u6c27\u8207\u81ea\u7531\u57fa\u6703\u9020\u6210\u7d30\u80de\u5167\u86cb\u767d\u8cea\u3001\u6838\u9178\u8207\u8102\u8cea\u904e\u6c27\u5316\uff0c\u9032\u800c\u7834\u58de\u7d44\u7e54\u3001\u751f\u7269\u9ad4\u4e4b\u6b63\u5e38\u529f\u80fd(\u9673\u8207\u984f\uff0c1998)\u3002Yu \u7b49\u767c\u73fe\u5929\u7136\u7684\u51ac\u87f2\u590f\u8349\u8207\u683d\u690d\u7684\u86f9\u87f2\u8349\u6c34\u8403\u7269\u7686\u80fd\u5920\u6291\u5236LDL \u904e\u6c27\u5316(Yu et al.,2006)\uff0c \u838a\u7b49\u4ee5\u4eba\u5de5\u57f9\u690d\u7684\u8836\u86f9\u87f2\u8349\u4ee5\u6c34\u8403\u8207100%\u9152\u7cbe\u8403\u53d6\u9032\u884c\uff0c\u767c\u73fe\u5169\u8005\u7686\u5177\u6709\u986f\u8457\u7684\u6e05\u9664DPPH \u81ea\u7531\u57fa\u4ee5\u53ca\u87af\u5408\u4e9e\u9435\u7b49\u6297\u6c27\u5316\u80fd\u529b\uff0c\u5c24\u5176\u662f\u6c34\u8403\u7269\u5728\u7d93\u904e\u4e94\u5929\u5f8c\u4ecd\u80fd\u6709\u6548\u6e1b\u5c11\u6cb9\u8102\u6c27\u5316\u7684\u73fe\u8c61(\u838a\u7b49\uff0c2003)\uff0c\u4ee3\u8868\u5176\u4e2d\u6240\u542b\u7684\u6297\u6c27\u5316\u6210\u4efd\u76f8\u7576\u7a69\u5b9a\uff0c\u986f\u793a\u4ee5\u767c\u9175\u4ee5\u53ca\u87f2\u9ad4\u990a\u6b96\u7684\u4eba\u5de5\u57f9\u80b2\u87f2\u8349\u7522\u54c1\u78ba\u5be6\u5177\u5099\u6297\u6c27\u5316\u80fd\u529b\u3002\u800c\u5728\u5be6\u9a57\u4e2d\u6240\u4f7f\u7528\u7684\u7c73\u57fa\u683d\u690d\u86f9\u87f2\u8349\u4e0d\u8ad6\u662f\u5728\u5b50\u5be6\u9ad4\u6216\u83cc\u7d72\u9ad4\u7686\u6709\u660e\u986f\u7684\u6297\u6c27\u5316\u529b\uff0c\u7c73\u57fa\u683d\u690d\u86f9\u87f2\u8349\u5728\u87af\u5408\u4e9e\u9435\u80fd\u529b\u4e0a\u751a\u81f3\u52dd\u904e\u91ce\u751f\u51ac\u87f2\u590f\u8349\u6c34\u8403\u7269\uff0c\u986f\u793a\u9019\u4e9b\u4eba\u5de5\u683d\u690d\u7684\u7522\u54c1\u78ba\u5be6\u5177\u6709\u5927\u91cf\u7684\u6297\u6c27\u5316\u7269\u8cea\u3002<\/p>\n
Grivennikov \u7b49\u6307\u51fa\u6162\u6027\u767c\u708e\u6703\u589e\u52a0\u7f79\u764c\u7684\u98a8\u96aa\uff0c\u800c\u816b\u7624\u767c\u751f\u5f8c\uff0c\u7576\u56fa\u614b\u816b\u7624\u5167\u90e8\u7d30\u80de\u56e0\u7f3a\u6c27\u58de\u6b7b\u5f8c\u6703\u5438\u5f15tumor association macrophage \u805a\u96c6\uff0c\u5206\u6cccpro-inflammation cytochine\uff0c\u4fc3\u9032\u816b\u7624\u7d30\u80de\u7684\u589e\u751f\u8207\u8840\u7ba1\u65b0\u751f\uff0c \u56e0\u6b64\u6291\u5236\u767c\u708e\u53cd\u61c9\u662f\u6297\u764c\u4e2d\u7684\u91cd\u8981\u8b70\u984c(Grivennikov et al., 2010)\u3002Won \u7b49\u4ee5\u8836\u86f9\u683d\u690d\u4e4b\u83cc\u7d72\u9ad4\u53ca\u5b50\u5be6\u9ad4\u7d93\u9152\u7cbe\u8403\u53d6\u5f8c\uff0c\u80fd\u6709\u6548\u6e1b\u5c11RAW \u7522\u751fnitrite \u8207iNOS protein\uff0c\u4e26\u6e1b\u5c11\u5c0f\u9f20\u8033\u90e8\u56e0\u767c\u708e\u5f15\u8d77\u7684\u816b\u8139(Won and Park, 2005)\uff0c\u53e6\u6709\u7814\u7a76\u7d14\u5316\u51fa\u86f9\u87f2\u8349\u4e2d\u6240\u542b\u7684\u87f2\u8349\u7d20\u80fd\u5920\u6e1b\u5c11\u767c\u708e\u56e0\u5b50\u5305\u62ecNO\u3001IL-1 beta\u3001IL-6 \u548cTNF-alpha \u7684\u7522\u751f(Kim et al., 2006b; Shin et al., 2009)\uff0c\u540c\u6a23\u5f9e\u86f9\u87f2\u8349\u8403\u53d6\u51fa\u7684\u591a\u7cd6\u9ad4(CPS-1)\u4ea6\u5177\u6709\u76f8\u4f3c\u529f\u6548 (Yu et al., 2004)\u3002\u5728\u7c73\u57fa\u683d\u690d\u86f9\u87f2\u8349\u5b50\u5be6\u9ad4\u548c\u83cc\u7d72\u9ad4\u4e0d\u8ad6\u5728\u9152\u8403\u6216\u6c34\u8403\u7686\u6709\u986f\u8457\u6291\u5236RAW \u91cb\u653e NO \u4e4b\u529f\u6548\uff0c\u5728\u4f4e\u6fc3\u5ea6\u6642\u9152\u8403\u7269\u6291\u5236\u6548\u679c\u9ad8\u65bc\u6c34\u8403\u7269\uff1b\u9152\u8403\u7269\u4e2d\u7c73\u57fa\u683d\u690d\u86f9\u87f2\u8349\u7684\u6291\u5236\u6548\u7387\u6c92\u6709\u5dee\u7570\uff0c\u4f46\u5728\u6c34\u8403\u7269\u4e2d\u7c73\u57fa\u683d\u690d\u86f9\u87f2\u8349\u5b50\u5be6\u9ad4\u6291\u5236\u6548\u679c\u9ad8\u65bc\u83cc\u7d72\u9ad4\uff0c\u986f\u793a\u7c73\u57fa\u683d\u690d\u7684\u86f9\u87f2\u8349\u5b50\u5be6\u9ad4\u4e2d\u7684\u6297\u767c\u708e\u7269\u8cea\u53ef\u80fd\u9ad8\u65bc\u83cc\u7d72\u9ad4\u3002<\/p>\n
\u53c3\u8003\u6587\u737b:
\n \u4f55\u601d\u598d\u30022010\u3002\u7c73\u57fa\u683d\u690d\u86f9\u87f2\u8349\u5b50\u5be6\u9ad4\u6291\u5236\u80ba\u764c\u751f\u9577\u4e4b\u7814\u7a76\u3002\u98df\u54c1\u79d1\u5b78\u7cfb\uff0c\u78a9\u58eb\u8ad6\u6587\uff0c\u570b\u7acb\u81fa\u7063\u6d77\u6d0b\u5927\u5b78\u3002
\n \u884c\u653f\u9662\u885b\u751f\u7f72\u4e2d\u91ab\u85e5\u59d4\u54e1\u6703\u30021985\u3002\u4e2d\u83ef\u6c11\u570b\u4e2d\u85e5\u5178\u7bc4\u3002\u884c\u653f\u9662\u885b\u751f\u7f72\u3002\u53f0\u5317\u3002pp. 669-670\u3002
\n \u6842\u4ef2\u722d\u3001\u6731\u96c5\u7d05\u30022008\u3002\u86f9\u87f2\u8349\u7684\u4eba\u5de5\u57f9\u80b2\u3001\u6709\u6548\u6210\u5206\u5206\u6790\u8207\u85e5\u7406\u4f5c\u7528\u7814\u7a76\u9032\u5c55\u3002\u8836\u696d\u79d1\u5b78\u300234 (1)\u3002pp. 178-184\u3002
\n \u9673\u60e0\u82f1\u3001\u984f\u570b\u6b3d\uff0c1998\uff0c\u81ea\u7531\u57fa\u3001\u6297\u6c27\u5316\u9632\u79a6\u8207\u4eba\u9ad4\u5065\u5eb7\uff0c\u4e2d\u83ef\u6c11\u570b\u71df\u990a\u5b78\u6703\u96dc\u8a8c\u300223\u3002pp. 105-121\u3002
\n \u838a\u66c9\u8389\u3001\u674e\u7965\u9e9f\u3001\u9673\u9999\u862d\u3001\u9ec3\u6a80\u6eaa\u3002\u8836\u86f9\u87f2\u8349\u4e4b\u7279\u9ede\u8207\u5b89\u5168\u6027\uff0cFungal Science\u30022003\u300218 (3&4)\u3002pp. 151-161\u3002
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\n Won, S.Y., and Park, E.H. (2005). Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J Ethnopharmacol 96, 555-561.
\n Wu, J.Y., Zhang, Q.X., and Leung, P.H. (2007). Inhibitory effects of ethyl acetate extract of Cordyceps sinensis mycelium on various cancer cells in culture and B16 melanoma in C57BL\/6 mice. Phytomedicine 14, 43-49.
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\n Yue, G.G., Lau, C.B., Fung, K.P., Leung, P.C., and Ko, W.H. (2008). Effects of Cordyceps sinensis, Cordyceps militaris and their isolated compounds on ion transport in Calu-3 human airway epithelial cells. J Ethnopharmacol 117, 92-101.<\/p>\n","protected":false},"excerpt":{"rendered":"
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